Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation

• US 5,683,422 A
• Filed: 04/25/1996
• Issued: 11/04/1997
• Est. Priority Date: 04/25/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Rise, Mark T.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/637,440
• Time in Patent Office: 558 Days
• Field of Search: 607/2, 607/43, 607/45, 607/54, 607/58, 607/67, 607/72, 607/117, 607/118, 607/116, 607/139-141
• US Class Current: 607/2
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36171 Frequency

Abstract

Techniques for stimulating the brain to reduce the effects of neurodegenerative disorders by means of an implantable signal generator and electrode. A sensor is used to detect the symptoms resulting from the disorder. A microprocessor algorithm analyzes the output from the sensor in order to regulate the stimulation delivered to the brain.

Claims

1. A method of therapeutically treating a neurodegenerative disorder by means of a signal generator and an implantable electrode having a proximal end and a stimulation portion comprising the steps of:

surgically implanting said electrode in a brain of a patient so that the stimulation portion lies in communication with a predetermined treatment site in the brain, said predetermined treatment site being selected from the group consisting of the ventrolateral thalamus (Thal), internal segment of globus pallidus (GPi), substantia nigra pars reticulata (SNr), striatopallidal fiber pathway, neostriatum, external segment of globus pallidus (Gpe), and external segment of globus pallidus to subthalamic nucleus fiber pathway;

coupling said proximal end of said electrode to said signal generator; and

operating said signal generator to stimulate said predetermined treatment site in the brain,

whereby the effects of said neurodegenerative disorder are reduced.

2. A method, as claimed in claim 1, wherein said neurodegenerative disorder is Parkinson'"'"'s disease and wherein said stimulation is selected to increase thalamic output.

3. A method, as claimed in claim 2, wherein said stimulation increases excitement of the thalamus or decreases inhibition of the thalamus.

4. A method, as claimed in claim 3, wherein said stimulation increases inhibition or decreases excitation of said internal segment of globus pallidus (GPi) or substantia nigra pars reticulata (SNr).

5. A method, as claimed in claim 3, wherein said stimulation increases excitation or decreases inhibition of said external segment of globus pallidus (GPe).

6. A method, as claimed in claim 1, wherein said step of operating said signal generator comprises the step of operating said signal generator in a high frequency range of 50 to 2500 Hz and stimulating a portion of the brain selected from the group consisting of the internal segment of globus pallidus (Gpi), substantia nigra pars reticulata (SNr) and the neostriatum.

7. A method, as claimed in claim 1, wherein said step of operating said signal generator comprises the step of operating said signal generator in a low frequency range of 2 to 100 Hz and stimulating a portion of the brain selected from the group consisting of the ventrolateral thalamus (Thal), striatopallidal fiber pathway, neostriatum, external segment of globus pallidus (Gpe), and external segment of globus pallidus to subthalamic nucleus fiber pathway.

8. A method of treating a netrodegenerative disorder characterized by hyperexcitation comprising in combination:

implanting a signal generator in a body of a patient;

implanting at least one electrode in a brain within said body so that a stimulation portion of said at least one electrode lies in communication with at least one predetermined treatment site in said brain, said at least one predetermined treatment site being selected from group consisting of the ventrolateral thalamus (Thal), internal segment of globus pallidus (GPi), substantia nigra pars reticulata (SNr), striatopallidal fiber pathway, neostriatum, external segment of globus pallidus (Gpe), and external segment of globus pallidus to subthalamic nucleus fiber pathway;

coupling said at least one electrode to said signal generator;

stimulating said at least one predetermined treatment site in said brain using said at least one electrode;

generating a sensor signal related to the extent of hyperexcitation exhibited by a portion of said brain; and

regulating said step of stimulating in response to said sensor signal, whereby stimulation is increased in response to an increase in hyperexcitation of said brain, and is decreased in response to a decrease in hyperexcitation of said brain.

9. A method, as claimed in claim 8, wherein said neurodegenerative disorder is Parkinson'"'"'s disease and wherein said step of stimulating is preformed to increase thalamic output.

10. A method, as claimed in claim 9, wherein said step of stimulating increases excitement of the thalamus or decreases inhibition of the thalamus.

11. A method, as claimed in claim 10, wherein said step of stimulating increases inhibition or decreases excitation of said internal segment of globus pallidus (GPi) or substantia nigra pars reticulata (SNr).

12. A method, as claimed in claim 10, wherein said step of stimulating increases excitation or decreases inhibition of said external segment of globus pallidus (Gpe).

13. A method, as claimed in claim 8, wherein said signal generator operates in a high frequency range of 50 to 2500 Hz and said at least one predetermined treatment site in said brain is selected from the group consisting of said internal segment of globus pallidus (Gpi), substantia nigra pars reticulata (Snr), and neostriatum.

14. A method, as claimed in claim 8, wherein said signal generator operates in a low frequency range of 2 to 100 Hz and said at least one predetermined treatment site in said brain is selected from the group consisting of said ventrolateral thalamus (Thal), striatopallidal fiber pathway, neostriatum, external segment of globus pallidus (Gpe), and external segment of globus pallidus to subthalamic nucleus fiber pathway.