Non-invasive monitoring and treatment of subjects in cardiac arrest using ECG parameters predictive of outcome

• US 5,683,424 A
• Filed: 06/13/1996
• Issued: 11/04/1997
• Est. Priority Date: 08/30/1994
• Status: Expired due to Fees

• Current Assignee: The Ohio State University Research Foundation
• Original Assignee: The Ohio State University Research Foundation
• Inventors: Dzwonczyk, Roger R., Brown, Charles G.
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US08/663,482
• Time in Patent Office: 509 Days
• Field of Search: 607/5, 607/7, 128/696, 128/697, 128/702, 128/704, 128/705, 128/708, 128/200.24, 364/413.05, 364/413.06, 604/890.1, 604/891.1
• US Class Current: 607/5
• CPC Class Codes: A61N 1/3925 Monitoring; Protecting

Abstract

A method and apparatus for determining the metabolic state of the myocardium of a subject in ventricular fibrillation or asystole and/or for guiding therapeutic interventions. Electrocardiogram signals of the subject'"'"'s heart are transformed to a frequency domain power spectrum, and at least one frequency parameter is monitored and processed to a value predictive of a clinically relevant cardiac arrest outcome. In the preferred embodiment, centroid frequency and/or peak power frequency of the power spectrum are monitored.

Claims

1. An apparatus that non-intrusively provide a clinically useful indicator of the condition of the heart of a subject in ventricular fibrillation or asystole from an electrocardiogram of the heart, said electrocardiogram made up of time domain sample of electrical signals, comprising:

an analyzer for transforming said domain samples of an electrocardiogram of a heart in one of ventricular fibrillation and asystole to a frequency domain power spectrum and for determining at least one parameter of said power spectrum that is predictive of a clinically relevant cardiac arrest outcome for the subject, said outcome being the subject surviving until an occurrence of at least one particular future event; and

a processor that resolves said at least one parameter to a clinically useful characteristic of the subject'"'"'s heart.

2. The apparatus in claim 1 wherein said processor resolves at least one of a centroid frequency of said power spectrum and a peak power frequency of said power spectrum to said clinically useful characteristic.

3. The apparatus in claim 2 wherein said processor determines whether said at least one of a centroid frequency and a peak power frequency is equal to or above a predetermined threshold.

4. The apparatus in claim 1 wherein said clinically useful characteristic of the subject'"'"'s heart is the metabolic state of the myocardium.

5. The apparatus in claim 1 wherein said at least one parameter includes at least two said parameters.

6. The apparatus in claim 5 wherein said at least two parameters includes the centroid frequency and peak power frequency of the power spectrum.

7. The apparatus in claim 1 including a display for displaying at least one of said at least one parameter and said clinically useful characteristic.

8. The apparatus in claim 1 including an event marker for receiving user input designations of the occurrence of events.

9. The apparatus in claim 1 wherein said at least one particular future event is selected from a group consisting of eventual return of spontaneous circulation of the subject, admission of the subject to a medical care facility and discharge of the subject from a medical care facility.

10. An apparatus for guiding the administration of therapy to a subject in ventricular fibrillation or asystole from an electrocardiogram of the heart made up of time domain samples of analog electrical potential, comprising:

an analyzer for transforming said time domain samples of an electrocardiogram of a heart in one of ventricular fibrillation and asystole to a frequency domain power spectrum and for determining a value that is predictive of the subject surviving until occurrence of at least one particular future event based on said frequency domain power spectrum;

a processor coupled to said analyzer; and

at least one therapy-administering device coupled to and controlled by said processor for administering therapy to the subject;

wherein said processor is adapted to controlling said therapy-administering device as a function of said value.

11. The apparatus in claim 10 wherein said therapy-administering device is a drug infusion device.

12. The apparatus in claim 11 wherein said processor selects a type and dosage of a drug to be administered by said drug infusion device as a function of said value.

13. The apparatus in claim 10 wherein said therapy-administering device is a defibrillator for administering a countershock.

14. The apparatus in claim 13 wherein said processor selects an electrical characteristic of a countershock to be administered by said defibrillator as a function of said value.

15. The apparatus in claim 14 wherein said electrical characteristic includes at least one of electrical energy and current.

16. The apparatus in claim 13 wherein said processor selects at least one of an electrical waveform to be administered by said defibrillator and a paddle position for said defibrillator as a function of said value.

17. The apparatus in claim 10 wherein said therapy-administering device is a cardiopulmonary resuscitator.

18. The apparatus in claim 17 wherein said processor selects at least one of a rate of compression, a depth of compression and a force of compression for said cardiopulmonary resuscitator as a function of said value.

19. The apparatus in claim 17 wherein said therapy administering device further includes a ventilator and wherein said processor selects a compression-to-ventilation ratio between said resuscitator and said ventilator as a function of said value.

20. The apparatus in claim 10 wherein said at least one particular future event is selected from a group consisting of eventual return of spontaneous circulation of the subject, admission of the subject to a medical care facility and discharge of the subject from a medical care facility.

21. An apparatus for guiding the administration of therapy to a subject in ventricular fibrillation or asystole from an electrocardiogram of the heart made up of time domain samples of analog electrical potential, comprising:

an analyzer for transforming said time domain samples of an electrocardiogram of a heart in one of ventricular fibrillation and asystole to a frequency domain power spectrum and for determining at least two frequency parameters that are predictive of a clinically relevant cardiac arrest outcome for the subject based upon said frequency domain power spectrum;

a processor coupled to said analyzer; and

at least one therapy-administering device coupled to and controlled by said processor for administering therapy to the subject;

wherein said processor is adapted to controlling said therapy-administering device as a function of said at least two frequency parameters.

22. The apparatus in claim 21 wherein said therapy-administering device is a drug infusion device.

23. The apparatus in claim 22 wherein said processor selects a type and dosage of a drug to be administered by said drug infusion device as a function of said at least two frequency parameters.

24. The apparatus in claim 21 wherein said therapy-administering device is a defibrillator for administering a countershock.

25. The apparatus in claim 24 wherein said processor selects an electrical characteristic of a countershock to be administered by said defibrillator as a function of said at least two frequency parameters.

26. The apparatus in claim 25 wherein said electrical characteristic includes at least one of electrical energy and current.

27. The apparatus in claim 24 wherein said processor selects at least one of an electrical waveform to be administered by said defibrillator and a paddle position for said defibrillator as a function of said at least two frequency parameters.

28. The apparatus in claim 21 wherein said therapy-administering device is a cardiopulmonary resuscitator.

29. The apparatus in claim 28 wherein said processor selects at least one of a rate of compression, a depth of compression and a force of compression for said cardiopulmonary resuscitator as a function of said at least two frequency parameters.

30. The apparatus in claim 28 wherein said therapy administering device further includes a ventilator and wherein said processor selects a compression-to-ventilation ratio between said resuscitator and said ventilator as a function of said parameters.

31. The apparatus in claim 21 wherein said at least two frequency parameters are predictive of the subject surviving until the occurrence of at least one of eventual return of spontaneous circulation, admission of the subject to a medical care facility and discharge of the subject from a medical care facility.

32. The apparatus in claim 21 wherein said at least two frequency parameters include peak power frequency of said power spectrum and centroid frequency of said power spectrum.