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DNA meltometer

  • US 5,683,657 A
  • Filed: 06/05/1995
  • Issued: 11/04/1997
  • Est. Priority Date: 03/24/1994
  • Status: Expired due to Fees
First Claim
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1. An nucleic acid analysis apparatus comprising, in combination,a thermomodulating chamber, wherein a temperature is defined, and wherein the thermomodulating chamber comprises a first opening and a second opening, wherein each of the openings is connected with a pumping means for passing a buffer solution through the thermomodulating chamber;

  • heating and cooling means that are in thermal contact with the thermomodulating chamber, for controlling the temperature of the thermomodulating chamber further comprising a nucleic acid retaining means; and

    a detecting means for detecting thermally-denatured double-stranded DNA at a temperature that is about the Tm of each nucleic acid to be analyzed, wherein the detecting means is connected to one of the openings in the thermomodulating chamber to allow the buffer solution to flow from the thermomodulating chamber and past the detecting means, and thereby sizing, quantitating, probing or sequencing the nucleic acid.

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