Medicinal aerosol formulations

• US 5,683,677 A
• Filed: 05/31/1995
• Issued: 11/04/1997
• Est. Priority Date: 12/06/1988
• Status: Expired due to Term

• Current Assignee: 3M Innovative Properties Company (3M Company)
• Original Assignee: Riker Laboratories, Inc. (3M Company)
• Inventors: Greenleaf, David J., Purewal, Tarlochan S.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Benston, Jr., William E.
• Application Number:
  US08/455,012
• Time in Patent Office: 888 Days
• Field of Search: 424/45, 424/43, 424/44, 424/46
• US Class Current: 424/45
• CPC Class Codes: A61K 9/008 comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
• CPC Class Codes: A61K 9/124 characterised by the propellant

Abstract

A self-propelling aerosol formulation which may be free from CFC'"'"'s which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.

Claims

1. A medicinal aerosol formulation, comprising:

(a) a therapeutically effective amount of a medicament;

(b) a propellant substantially free of chlorofluorocarbons and comprising 1,1,1,2-tetrafluoroethane; and

(c) wherein the medicament is fully dissolved in the formulation, and said formulation is suitable for delivery by inhalation.

2. The medicinal aerosol formulation of claim 1, further including at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane, selected from the group consisting of ethyl alcohol, isopropyl alcohol, n-pentane, isopentane, neopentane, and isopropyl myristate.

3. The medicinal aerosol formulation of claim 2, wherein said compound is ethyl alcohol.