Apparatus and method for compensation of magnetic susceptibility variation in NMR microspectroscopy detection microcoils
First Claim
1. A nuclear magnetic resonance microspectroscopy detection microcoil assembly, comprising:
- a microcoil having at least one conductor turn having a first magnetic susceptability; and
a susceptibility matching medium at least partially surrounding the at least one conductor turn;
wherein a second magnetic susceptibility of the susceptibility matching medium substantially matches the first magnetic susceptability of the microcoil and thereby reduces distortions in a static magnetic field surrounding the microcoil.
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Abstract
An apparatus and method for compensation of magnetic susceptibility variation in NMR microspectroscopy detection microcoils. NMR detection microcoils are formed with side-by-side windings in order to approximate a uniform cylindrical sheet coil. The wire may have a thin layer of insulation in order to prevent shorting between adjacent turns, or (if the wire diameter is small enough) uninsulated wire may be wound with the adjacent turns touching without fear of shorting between coil turns. Additionally, a susceptibility matching medium, such as a perfluorinated hydrocarbon, may be placed around the microcoil to minimize susceptibility-induced variations in the B0 magnetic field.
82 Citations
15 Claims
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1. A nuclear magnetic resonance microspectroscopy detection microcoil assembly, comprising:
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a microcoil having at least one conductor turn having a first magnetic susceptability; and a susceptibility matching medium at least partially surrounding the at least one conductor turn; wherein a second magnetic susceptibility of the susceptibility matching medium substantially matches the first magnetic susceptability of the microcoil and thereby reduces distortions in a static magnetic field surrounding the microcoil. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for compensation of magnetic susceptibility variation in NMR microspectroscopy detection microcoils, comprising the steps of:
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(a) forming a detection microcoil having a first magnetic susceptability; and (b) at least partially surrounding the microcoil with a susceptibility matching medium, wherein a second magnetic susceptibility of the susceptibility matching medium substantially matches the first magnetic susceptability of the microcoil and thereby reduces distortions in a static magnetic field surrounding the microcoil. - View Dependent Claims (14)
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15. A nuclear magnetic resonance microspectroscopy detection system, comprising:
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means for generating a static magnetic field; a detection microcoil positioned within the static magnetic field, the microcoil comprising; a microcoil having a first magnetic susceptability a susceptibility matching medium at least partially surrounding the microcoil; wherein a second magnetic susceptibility of the susceptibility matching medium substantially matches the first magnetic susceptability of the microcoil and thereby reduces distortions in a static magnetic field surrounding the microcoil; means for transmitting and receiving electrical signals to and from the microcoil; and control means for controlling the means for transmitting and receiving.
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Specification