Dialysis process and system
First Claim
1. In a dialysis process incorporating a dialyzer for the removal of impurities from a flowing supply of blood to a flowing supply of fresh dialysate from a main supply of dialysate by means of a dialysis membrane separating the flowing supply of blood from flowing supply of fresh dialysate, the improvement comprising:
- providing a closed dialysate recirculation loop,discontinuing the flow of fresh dialysate to the dialyzer and recirculating the dialysate in said closed dialysate recirculation loop isolated from the main supply of dialysate until concentration equilibrium has been established between a solute in the blood and in the closed dialysate recirculation loop,analyzing the contents of the closed dialysate recirculation loop to determine the solute concentration,discontinuing recirculation in said closed dialysate recirculation loop and providing a flow of fresh dialysate to the dialyzer to continue normal dialysis,repeating the recirculation process at the end of the dialysis period to determine solute loss so as to permit the quantification of dialysis therapy and provide on-line prescription.
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Accused Products
Abstract
Disclosed is a method and apparatus for the quantification of solute removal during hemodialysis. The method relies upon discontinuing the flow of fresh dialysate to the dialyzer and recirculating the dialysate in a closed loop through the dialyzer. Recirculation is continued until a steady state concentration of solute (e.g. urea) in the dialysate is achieved. Analysis of the dialysate by suitable means at this time yields a value equal to the solute concentration in the blood without the need for blood sampling. Normal dialysis is resumed by discontinuing the recirculation and providing fresh dialysate to the dialyzer. Determination of solute concentrations at least at the beginning and end of the dialysis period allows the determination of solute loss and the quantification of dialysis therapy and its on-line prescription.
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Citations
6 Claims
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1. In a dialysis process incorporating a dialyzer for the removal of impurities from a flowing supply of blood to a flowing supply of fresh dialysate from a main supply of dialysate by means of a dialysis membrane separating the flowing supply of blood from flowing supply of fresh dialysate, the improvement comprising:
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providing a closed dialysate recirculation loop, discontinuing the flow of fresh dialysate to the dialyzer and recirculating the dialysate in said closed dialysate recirculation loop isolated from the main supply of dialysate until concentration equilibrium has been established between a solute in the blood and in the closed dialysate recirculation loop, analyzing the contents of the closed dialysate recirculation loop to determine the solute concentration, discontinuing recirculation in said closed dialysate recirculation loop and providing a flow of fresh dialysate to the dialyzer to continue normal dialysis, repeating the recirculation process at the end of the dialysis period to determine solute loss so as to permit the quantification of dialysis therapy and provide on-line prescription. - View Dependent Claims (2)
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3. In a hemodialysis system having a dialyzer, means for providing a supply of dialyzer fluid to said dialyzer and means for circulating blood from a patient through said dialyzer and back to the patient, and means for removing dialyzer-fluid from said dialyzer, the improvement comprising:
a dialyzer fluid recirculation passage connected to said dialyzer for recirculating at least some of the removed dialyzer fluid through said dialyzer one or more times, and an analyzer for analyzing dialyzer fluid in said recirculation passage. - View Dependent Claims (4, 5, 6)
Specification