Controlled release formulations for the treatment of xerostomia

• US 5,686,094 A
• Filed: 04/01/1991
• Issued: 11/11/1997
• Est. Priority Date: 04/01/1991
• Status: Expired due to Term

• Current Assignee: Watson Pharmaceuticals, Inc. (Abbvie Incorporated)
• Original Assignee: Theratech, Inc. (Dynatronics Corporation)
• Inventors: Acharya, Ramesh N.
• Primary Examiner(s): Bawa, Raj
• Application Number:
  US07/678,814
• Time in Patent Office: 2,416 Days
• Field of Search: 424/486, 424/484, 424/422, 424/434, 424/435, 424/439, 424/499, 514/953
• US Class Current: 424/434
• CPC Class Codes: A61K 8/733 Alginic acid; Salts thereof
• CPC Class Codes: A61K 8/8147 Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 9/006 Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
• CPC Class Codes: A61K 9/2027 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/205 Polysaccharides, e.g. alginate, gums; Cyclodextrin
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

A polymeric delivery system which is formed by a polycarbophil type composition with an active agent, optionally in the presence of water and/or other cosolvent. The resulting product is especially useful as a carrier or coating of active compositions, such as pharmaceuticals and the like. The composition is also useful for the controlled or sustained release of active agents that are drugs, cosmetic agents, household agents, agricultural agents, industrial chemical agents and nutritional agents. A composition and method for the treatment of xerostomia is also disclosed, comprising polycarbophil in the form of an article having a shape suitable for insertion into the mouth.

Claims

1. A method for treating xerostomia comprising contacting an oral mucosa of a patient with a shaped polymeric delivery system/device comprising calcium polycarbophil containing about 1 to about 10 ml of water and maintaining said polymeric delivery system/device in contact with the oral mucosa thereby to hydrate the oral mucosa with a sufficient amount of water to treat xerostomia.

2. The method of claim 1, wherein the shaped system/device further comprises an active medicament.

3. The method of claim 1, wherein the shaped system/device further comprises a lubricant.

4. The method of claim 1, wherein the shaped system/device further comprises a flavorant.