Methods for screening for agents which modulate telomere length
First Claim
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1. A method for screening for agents which modulate telomere length, wherein said method comprises the steps of:
- (a) contacting cells in vitro with an agent which potential modulates telomere length;
(b) measuring the length of telomeres in cells contacted with said agent and in cells not contacted with said agent, and(c) correlating a difference in telomere length in cells contacted with said agent as compared to cells not contacted with said agent identification of an agent which modulates telomere length.
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Abstract
Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
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9 Claims
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1. A method for screening for agents which modulate telomere length, wherein said method comprises the steps of:
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(a) contacting cells in vitro with an agent which potential modulates telomere length; (b) measuring the length of telomeres in cells contacted with said agent and in cells not contacted with said agent, and (c) correlating a difference in telomere length in cells contacted with said agent as compared to cells not contacted with said agent identification of an agent which modulates telomere length. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification