Composition and method for revitalizing scar tissue

• US 5,686,425 A
• Filed: 06/05/1995
• Issued: 11/11/1997
• Est. Priority Date: 07/10/1991
• Status: Expired due to Term

• Current Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Original Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Inventors: Lee, Clarence C.
• Primary Examiner(s): Sayala, Chhaya D.
• Application Number:
  US08/463,886
• Time in Patent Office: 890 Days
• Field of Search: 530/356, 530/357, 530/399, 424/85.1, 424/85.2, 424/450, 514/21, 514/801, 623/11
• US Class Current: 424/488
• CPC Class Codes: A61K 31/557 Eicosanoids, e.g. leukotrienes or prostaglandins
• CPC Class Codes: A61K 38/1841 Transforming growth factor [TGF]
• CPC Class Codes: A61K 38/1858 Platelet-derived growth factor [PDGF]
• CPC Class Codes: A61K 38/27 Growth hormone [GH], i.e. somatotropin
• CPC Class Codes: A61K 38/30 Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2 insulin-like growth factor binding protein A61K38/1754
• CPC Class Codes: A61K 38/39 Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• CPC Class Codes: A61K 9/1611 Inorganic compounds
• CPC Class Codes: A61K 9/1652 Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin homeopathic globules A61K9/1623
• CPC Class Codes: A61K 9/1658 Proteins, e.g. albumin, gelatin
• CPC Class Codes: A61P 13/02 of urine or of the urinary tract, e.g. urine acidifiers
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A composition and method are provided that are effective in revitalizing scar tissue by introducing a bioactive substance having angiogenic activity into the scar tissue. The bioactive substance can be introduced by itself, or it can be introduced into the scar tissue in a timed release form. The present invention is effective in treating stress urinary incontinence or localized muscular dysfunction.

Claims

1. A method for revitalizing scar tissue in a human or animal comprising injecting in hardened scar tissue a composition comprising a bioactive material selected from the group consisting of a growth factor and a growth hormone, and a biodegradable matrix, wherein the composition expands, softens and restores elasticity to the hardened scar tissue when injected into the scar tissue.

2. The method of claim 1, wherein the biodegradable matrix is selected from the group consisting of hyaluronic acid, alginate, agarose, and dextran.

3. The method of claim 1, wherein the growth factor is fibronectin.

4. The method of claim 1, wherein the growth factor is a fibroblast receptor binding peptide segment.

5. The method of claim 1, wherein the bioactive material is a growth hormone.

6. The method of claim 1, wherein the growth factor is insulin-like growth factor.

7. The method of claim 1, wherein the growth factor is platelet-derived growth factor.

8. The method of claim 1, wherein the growth factor is transforming growth factor.

9. The method of claim 1, wherein the growth factor is transforming growth factor beta.

10. The method of claim 1, wherein the growth factor is transforming growth factor alpha.