Syringe

• US 5,688,252 A
• Filed: 09/28/1995
• Issued: 11/18/1997
• Est. Priority Date: 09/30/1994
• Status: Expired due to Fees

• Current Assignee: Takeda Pharmaceutical Company Limited
• Original Assignee: Takeda Chemical Industries, Ltd. (Takeda Pharmaceutical Company Limited)
• Inventors: Matsuda, Terumi, Tanaka, Nobuo
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US08/535,915
• Time in Patent Office: 782 Days
• Field of Search: 604/218, 604/228, 604/89, 604/91, 604/187, 604/110, 604/220
• US Class Current: 604/218
• CPC Class Codes: A61M 2005/287 by displacing occluding plugs
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/284 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61M 5/31515 Connection of piston with piston rod

Abstract

A syringe has a tubular body provided at its front end portion with a portion for mounting an injection needle thereon and opens at its rear end portion so as to have a rear end opening. A gasket for sealing the rear end opening of the tubular body is slidably inserted into the tubular body. A plunger rod is detachably coupled with a rear end portion of the gasket through the rear end opening of the tubular body. A male screw is formed at a front end portion of the plunger rod and is circumferentially alternately divided into at least one male screw portion and at least one first recess portion. A female screw is formed on a rear end face of the gasket and is circumferentially alternately divided into at least one female screw portion and at least one second recess portion. A state where the male screw portion and the first recess portion of the male screw are, respectively, fitted into the second recess portion and the female screw portion of the female screw, the male screw is rotated relative to the female screw so as to be brought into engagement with the female screw such that the plunger rod is coupled with the gasket.

Claims

1. A syringe comprising:

a tubular body which is provided, at its front end portion, with a portion for mounting an injection needle thereon and opens at its rear end portion so as to have a rear end opening;

a gasket for sealing the rear end opening of the tubular body, which is slidably inserted into the tubular body; and

a plunger rod which is detachably coupled with a rear end portion of the gasket through the rear end opening of the tubular body;

wherein said plunger comprises a rod portion having a front end, a small-diameter rod portion extending forwardly from said front end of said rod portion along an axis of said rod portion, said small-diameter rod portion having a diameter smaller than the diameter of said rod portion, and a pair of opposite engagement projections that extend radially outward at a front end portion of said small-diameter rod portion, whereby an elongate front end portion of said plunger rod is defined by said front end portion of said small-diameter rod portion and said engagement projections;

wherein said gasket is slidably inserted into and seals said rear end opening of said tubular body, said gasket having a rear end portion that is capable of having said plunger rod detachably coupled therewith, said rear end portion having a circular hollow therein for receiving said elongated front end portion of said plunger rod, said circular hollow having a mouth having a periphery from which a pair of opposed flanges project inward and have a central through hole therebetween for receiving said front end portion of said small-diameter rod portion therethrough and a pair of opposite recesses for receiving said engagement projections therethrough, whereby said central through hole and said pair of opposite recesses define an elongate rear end opening for receiving said front end portion of said plunger rod; and

a rotational stopping means for stopping rotation of said plunger rod in said gasket;

wherein when said plunger rod is rotated in said gasket to a predetermined position established by said rotational stopping means after said front end portion of said plunger rod has been inserted into said circular hollow through said elongate rear end opening of said gasket, said flanges can retain said engagement projections in said circular hollow.

2. The syringe of claim 1, wherein said means for frictionally securing comprises:

said at least one engagement member of said front end portion of said plunger rod comprising two helical thread portions; and

said complementary projection of said hollow of said gasket comprising two complementary helical thread portions engageable with said two helical thread portions of said front end portion of said plunger rod.

3. The syringe of claim 2, wherein said means for frictionally securing comprises said two helical thread portions and said two complementary helical thread portions being structurally arranged such that when said front end portion of said plunger rod is rotated about 1/4 of a full turn relative to said hollow when said at least one engagement member is engaged with said complementary recess, said helical thread portions engage said complementary helical thread portions and advance said front end portion into secure engagement with said hollow with substantially no play between said front end portion and said hollow.

4. The syringe of claim 2, wherein:

said recess of said front end portion comprises two recesses, and said complementary recess comprises two complementary recesses;

said two helical thread portions are separated from each other by said two recesses, each of said two recesses comprising flat circumferential portions; and

said two complementary helical thread portions are separated from each other by said two complementary recesses, each of said two complementary recesses comprising flat circumferential inner surfaces.

5. The syringe of claim 4, wherein each of said two recesses of said front end portion extends over an angle greater than 90 degrees, and each of said two complementary recesses extends over an angle greater than 90 degrees.

6. The syringe of claim 1, wherein said gasket comprises an outer portion made from a rubber or elastomer and a plastic member in said outer portion that defines said hollow.

7. The syringe of claim 1, wherein said engagement members each extend over an angle of about 90 degrees, and said recesses separate said two engagement projections, said recesses each extending over an angle of about 90 degrees and said engagement projections each extend over an angle of about 90 degrees.

8. The syringe of claim 1, wherein said flanges each have an inner face for engaging an outer face of said engagement members.

9. The syringe of claim 8, wherein said rotational stopping means comprises ribs adjacent to said engagement members for engaging said flanges and stopping rotation of said front end portion relative to said hollow.

10. The syringe of claim 8, wherein said hollow further comprises ribs as said means for stopping rotation on a bottom surface thereof for engaging said engagement members and stopping rotation of said front end portion relative to said hollow when said at least one engagement member is engaged with said complementary recess.

11. The syringe of claim 1, wherein said means comprises said at least one engagement member comprising two engagement members each extending over a circumferential angular extent, said recess comprising two recesses separating said two engagement members, said complementary recess comprising two complementary recesses each extending over an angular extent corresponding to the angular extent of said two engagement members, and said complementary projection comprising two complementary projections each extending over an angular extent corresponding to the angular extent of said two recesses.

12. A syringe comprising:

a tubular body having a front end portion adapted to have an injection needle mounted thereon and a rear end portion having a rear end opening;

a gasket slidably inserted into and sealing said rear end opening of said tubular body, said gasket having a rear end portion;

a plunger rod adapted to be detachably coupled with said rear end portion of said gasket, said plunger rod comprising a front end portion having an engagement projection member that projects radially outwardly thereof and has a predetermined angular extent;

a hollow in said rear end portion of said gasket for receiving said engagement projection member of said plunger rod, said hollow having a mouth with a periphery from which a flange projects radially inwardly and a recess for receiving said engagement projection member therethrough;

at least one movable sealing member disposed in said tubular body between said front end portion of said tubular body and said gasket dividing the interior of said tubular body into first and second compartments located at said front end portion and said rear end portion of said tubular body, respectively;

a medicament stored in said first compartment and a liquid vehicle stored in said second compartment;

a bulge portion in a side wall of said tubular body located such that when said sealing member is moved in response to movement of said gasket via said plunger rod said liquid medicament flows into said first compartment via said bulge portion; and

an engaging means for temporarily stopping advance of said plunger rod into said tubular body upon movement of said plunger rod into said tubular body at a first position at which said front end portion of said plunger rod has been inserted into said circular hollow of said gasket and at a second position at which said sealing member has been moved by said plunger rod, through said gasket, to a position at which said sealing member has a portion thereof advanced forwardly of a front end of said bulge portion.

13. The syringe of claim 12, wherein:

said protrusion of said finger grip is annular, has a central through-hole, and has a pair of radially extending slots open to said central through-hole;

said plunger rod has a rod portion of a cruciform sectional shape defined by a vertical frame and a horizontal frame;

said rod portion of said plunger extends from a position that is spaced a predetermined distance from said front end portion of said plunger rod to a rear end portion of said plunger rod, and is divided into a front region, an intermediate region and a rear region;

said vertical and horizontal frames have external shapes along said front region allowing said vertical and horizontal frames to be inserted through said central through-hole of finger grip;

said horizontal frame has an external shape along said intermediate region allowing said horizontal frame to be inserted into said central through-hole of said finger grip, and said vertical frame has an external shape along said intermediate region preventing said vertical frame from being inserted through said central through-hole and allowing said vertical frame to be inserted through said slots of said finger grip; and

said vertical frame has an external shape along said rear region allowing said vertical frame to be inserted through said central through-hole, and said horizontal frame has an external shape preventing said horizontal frame from being inserted through said central through-hole and allowing said horizontal frame to be inserted through said slots of said finger grip.

14. A syringe comprising:

a tubular body having a front end portion adapted to have an injection needle mounted thereon and a rear end portion having a rear end opening;

a plunger rod comprising a rod portion having a front end, a small-diameter rod portion extending forwardly from said front end of said rod portion along an axis of said rod portion, said small-diameter rod portion having a diameter smaller than the diameter of said rod portion, and a pair of opposite engagement projections that extend radially outward at a front end portion of said small-diameter rod portion, whereby an elongate front end portion of said plunger rod is defined by said front end portion of said small-diameter rod portion and said engagement projections;

a gasket slidably inserted into and sealing said rear end opening of said tubular body, said gasket having a rear end portion that is capable of having said plunger rod detachably coupled therewith, said rear end portion having a circular hollow therein for receiving said elongated front end portion of said plunger rod, said circular hollow having a mouth having a periphery from which a pair of opposed flanges project inward and have a central through hole therebetween for receiving said front end portion of said small-diameter rod portion therethrough and a pair of opposite recesses for receiving said engagement projections therethrough, whereby said central through hole and said pair of opposite recesses define an elongate rear end opening for receiving said front end portion of said plunger rod; and

a rotational stopping means for stopping rotation of said plunger rod in said gasket;

wherein when said plunger rod is rotated in said gasket to a predetermined position established by said rotational stopping means after said front end portion of said plunger rod has been inserted into said circular hollow through said elongate rear end opening of said gasket, said flanges can retain said engagement projections in said circular hollow.

15. The syringe of claim 14, wherein said gasket is made of a material selected from the group consisting of elastomer and rubber and said plunger rod is made of plastic.

16. The syringe of claim 14, wherein said tubular body comprises an injection liquid stored between said front end portion of said tubular body and said gasket.

17. The syringe of claim 14, and further comprising:

at least one movable sealing member disposed in said tubular body between said front end portion of said tubular body and said gasket dividing the interior of said tubular body into first and second compartments located at said front end portion and said rear end portion of said tubular body, respectively;

a medicament stored in said first compartment and a liquid vehicle stored in said second compartment; and

a bulge portion in a side wall of said tubular body located such that when said sealing member is moved in response to movement of said gasket via said plunger rod said liquid medicament flows into said first compartment via said bulge portion.

18. The syringe of claim 17, and further comprising:

an engaging means for temporarily stopping advance of said plunger rod into said tubular body upon movement of said plunger rod into said tubular body at a first position at which said front end portion of said plunger rod has been inserted into said circular hollow of said gasket and at a second position at which said sealing member has been moved by said plunger rod, through said gasket, to a position at which said sealing member has a portion thereof advanced forwardly of a front end of said bulge portion.

19. The syringe of claim 18, wherein:

a finger grip is mounted on said tubular body at said rear end portion of said tubular body, said finger grip comprising a protrusion that projects radially inward from the inner periphery of said tubular body; and

a projection member is located at a predetermined position on the outer periphery of said plunger rod such that advance of said plunger rod into said tubular body is temporarily stopped by contact of said projection member of said plunger rod with said protrusion of said finger grip; and

said protrusion and said projection member are arranged such that when said plunger rod is rotated relative to said finger grip after being stopped by contact of said projection member of said plunger rod with said protrusion of said finger grip, said projection member is moved out of contact with said protrusion of said finger grip so as to enable further advance of said plunger rod.

20. The syringe of claim 19, wherein:

said protrusion of said finger grip is annular, has a central through-hole, and has a pair of radially extending slots open to said central through-hole;

said rod portion of said plunger rod has a cruciform sectional shape defined by a vertical frame and a horizontal frame;

said rod portion of said plunger extends from a position that is spaced a predetermined distance from said front end portion of said plunger rod to a rear end portion of said plunger rod, and is divided into a front region, an intermediate region and a rear region;

said vertical and horizontal frames have external shapes along said front region allowing said vertical and horizontal frames to be inserted through said central through-hole of finger grip;

said horizontal frame has an external shape along said intermediate region allowing said horizontal frame to be inserted into said central through-hole of said finger grip, and said vertical frame has an external shape along said intermediate region preventing said vertical frame from being inserted through said central through-hole and allowing said vertical frame to be inserted through said slots of said finger grip; and

said vertical frame has an external shape along said rear region allowing said vertical frame to be inserted through said central through-hole, and said horizontal frame has an external shape preventing said horizontal frame from being inserted through said central through-hole and allowing said horizontal frame to be inserted through said slots of said finger grip.

21. The syringe of claim 14, wherein said rotational stopper means comprises a pair of first ribs each projecting from a rear portion of one of said engagement projections such that upon rotation of said plunger rod in said gasket said first ribs engage with said flanges such that rotation of said plunger rod in said gasket is stopped.

22. The syringe of claim 21, wherein said rotational stopper means comprises a pair of second ribs located in said circular hollow of said gasket such that upon rotation of said plunger rod in said gasket said second ribs engage with said engagement projections such that rotation of said plunger rod in said gasket is stopped.

23. The syringe of claim 14, wherein said rotational stopper means comprises a pair of second ribs located in said circular hollow of said gasket such that upon rotation of said plunger rod in said gasket said second ribs engage with said engagement projections such that rotation of said plunger rod in said gasket is stopped.