Non-receptor mediated imaging agents

• US 5,688,489 A
• Filed: 09/15/1995
• Issued: 11/18/1997
• Est. Priority Date: 09/15/1995
• Status: Expired due to Fees

• Current Assignee: Bracco Imaging S.p.A. (Bracco SPA)
• Original Assignee: Resolution Pharmaceuticals Inc.
• Inventors: Thornback, John, Pollak, Alfred, Goodbody, Anne, Peers, Susan H.
• Primary Examiner(s): Kight, John
• Assistant Examiner(s): JONES, DAMERON LEVEST
• Application Number:
  US08/529,060
• Time in Patent Office: 795 Days
• Field of Search: 424/1.11, 424/1.65, 424/1.69, 424/9.1, 530/300, 530/350, 530/324-330, 534/10, 534/14, 206/569
• US Class Current: 424/1.69
• CPC Class Codes: A61K 2123/00 Preparations for testing in vivo
• CPC Class Codes: A61K 51/088 conjugates with carriers being peptides, polyamino acids or proteins antibodies A61K51/10
• CPC Class Codes: C07K 14/001 by chemical synthesis
• CPC Class Codes: C07K 14/46 from vertebrates

Abstract

Detectably labelled non-receptor mediated cell-associating compounds are provided for use in the diagnostic imaging of target sites in a mammal. Cell-associating compounds may be directly labelled, or labelled via a chelating compound to form a conjugate. Such cell-associating compounds are particularly useful to image target sites such as tumour sites and sites of infection.

Claims

1. The compound, dimethyl-G-S-C(Acm)-β

A-β

A-β

A-G-I-G-K-F-L-H-S-A-G-K-F-G-K-A-F-V-G-E-I-M-K-S.

2. A non-receptor mediated cell-associating compound coupled to a detectable label, wherein said compound is selected from the group consisting of magainin peptides, and functionally equivalent analogues thereof, wherein said label is linked to said compound via a chelator comprising dimethylglycine-serine-cysteine (Acm).

3. A compound as defined in claim 2, wherein said chelator is linked to said compound via a linker, wherein said linker is selected from the group consisting of glycine-asparagine-glycine, and a linker consisting of from 1-5 β

-alanine residues.

4. A non-receptor mediated cell-associating compound coupled to a detectable label, wherein said compound is selected from the group consisting of magainin peptides, and functionally equivalent analogs thereof, wherein said label is linked to said compound via a chelator, wherein said chelator is linked to said compound via a linker, and said linker is selected from the group consisting of glycine-asparagine-glycine, and a linker consisting of from 1-5β

-alanine residues.