DNA encoding and methods for producing BMP-8 proteins
First Claim
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1. An isolated DNA sequence selected from the group consisting of(a) the nucleotide sequence set forth in SEQ ID NO:
- 13 comprising nucleotide #8 to #850; and
(b) nucleotide sequences which encode the amino acid sequence comprising amino acid #139 to #142 of SEQ ID NO;
14.
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Accused Products
Abstract
Purified cartilage and/or bone inductive proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
66 Citations
4 Claims
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1. An isolated DNA sequence selected from the group consisting of
(a) the nucleotide sequence set forth in SEQ ID NO: - 13 comprising nucleotide #8 to #850; and
(b) nucleotide sequences which encode the amino acid sequence comprising amino acid #139 to #142 of SEQ ID NO;
14. - View Dependent Claims (3)
- 13 comprising nucleotide #8 to #850; and
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2. An isolated DNA sequence selected from the group consisting of
(a) the nucleotide sequence set forth in SEQ ID NO: - 13 comprising nucelotide #434 to #850; and
(b) nucleotide sequences which encode the amino acid sequence comprising amino acid #4 to #142 of SEQ ID NO;
14. - View Dependent Claims (4)
- 13 comprising nucelotide #434 to #850; and
Specification
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Current AssigneeGenetics Institute LLC (Pfizer Inc.)
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Original AssigneeGenetics Institute LLC (Pfizer Inc.)
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InventorsWang, Jack H., Wozney, John M., Hewick, Rodney M., Celeste, Anthony J.
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Primary Examiner(s)Furman, Keith C.
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Application NumberUS07/800,364Time in Patent Office2,184 DaysField of Search536/27, 536/235, 536/23.51, 435/240.2, 435/69.1, 435/240.1, 435/252.3, 435/69.4US Class Current435/325CPC Class CodesA61K 38/00 Medicinal preparations cont...C07K 14/51 Bone morphogenetic factor; ...
