Detecting vascular stenosis in chronic hemodialysis patients

• US 5,690,115 A
• Filed: 09/21/1995
• Issued: 11/25/1997
• Est. Priority Date: 09/21/1995
• Status: Expired due to Term

• Current Assignee: Charles L. Feldman, Kenneth Kleinman, Thomas Shook
• Original Assignee: Charles L. Feldman, Kenneth Kleinman, Thomas Shook
• Inventors: Feldman, Charles L., Shook, Thomas, Kleinman, Kenneth
• Primary Examiner(s): JAWORSKI, FRANCIS J
• Application Number:
  US08/531,940
• Time in Patent Office: 796 Days
• Field of Search: 128/660.05-662.06, 128/691-692
• US Class Current: 600/454
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61M 1/3656 Monitoring patency or flow at connection sites; Detecting disconnections

Abstract

Stenotic regions in the vasculature of chronic hemodialysis patients are detected and monitored by blood velocity measuring.

Claims

1. A method of detecting an occlusion in a blood conduit of a hemodialysis patient comprising:

inserting a velocity detector into an examined blood conduit at a selected site;

measuring velocity of the blood flow in a first region of the examined blood conduit;

moving said velocity detector to a second region of the examined blood conduit;

measuring velocity of the blood flow in at least a second region of the examined blood conduit;

and comparing the velocities measured in the different regions to obtain an indication of an occlusion in said blood conduit.

2. The method of claim 1 wherein said inserting a velocity detector includes positioning said velocity detector into a distal region of the examined blood conduit and said moving said velocity detector include moving said velocity detector to a proximal region relative to said site.

3. The method of claim 1 wherein said inserting step includes introducing into the examined blood conduit a doppler catheter comprising a doppler transducer mounted substantially at its distal end.

4. The method of claim 3 wherein said inserting step includes positioning said doppler transducer at a distal region of the examined blood conduit relative to said site and said moving steps include retracting said doppler catheter.

5. The method of claim 4 wherein said retracting of said doppler catheter is performed at a substantially constant rate.

6. The method of claim 1 wherein said inserting step includes introducing into the examined blood conduit a doppler flow-wire comprising a doppler transducer mounted substantially at its distal end.

7. The method of claim 6 wherein said inserting step includes positioning said doppler transducer at a distal region of the examined blood conduit relative to said site and said moving steps include retracting said doppler flo-wire.

8. The method of claim 7 wherein said retracting of said doppler catheter is performed at a substantially constant rate.

9. The method of claim 6 wherein said doppler type measurement comprises,

introducing into said blood conduit a doppler catheter comprising a doppler transducer substantially at its distal end;

moving said doppler transducer to said region;

measuring a velocity of blood flow in said region;

moving said doppler transducer to said zone; and

measuring a velocity of blood flow in said zone.

10. The method of claim 9 wherein said cross-sectional area of said region A_n is related to the cross-sectional areas of said zone A_k and said catheter A_c by

11. The method of claim 10 wherein said velocity is a phasic velocity.

12. The method of claim 10 wherein said velocity is a mean velocity averaged over at least one heart beat.

13. The method of claim 9 further comprising controlling the orientation of said doppler transducer relative to the measured blood flow to achieve reliable velocity measurements.

14. The method of claim 9 wherein said velocity is a phasic velocity.

15. The method of claim 9 wherein said velocity is a mean velocity averaged over at least one heart beat.

16. The method of claim 9 further comprising:

moving said doppler transducer to a second region of said blood conduit;

measuring a velocity of blood flow in said second region; and

determining cross-sectional area of said second region based on said measured velocities.

17. The method of claim 16 further comprising the steps of forming a profile of said blood conduit by correlating said measured cross-sectional areas and their locations.

18. The method of claim 17 further comprising visually displaying said profile.

19. The method of claim 1 further comprising repeating the method of claim 1 at a later date and comparing the velocity measurement provided by the method of claim 1 at an earlier date with that at a later date.

20. A system for detecting a partial occlusion in a blood conduit of a hemodialysis patient comprising:

a velocity detector insertable into different regions of an examined blood conduit at a selected site used for hemodialysis access, said velocity detector constructed to provide velocity signals representative of velocity of the blood flow at said different regions; and

a processor constructed to receive said velocity signals from said detector and arranged to compare said velocity signals measured at different regions of the examined blood conduit to create a velocity profile.

21. The system of claim 20 wherein said velocity detector is a doppler type detector.

22. The system of claim 21 wherein said doppler type detector includes

a doppler catheter comprising a proximal end and a distal end;

a doppler transducer mounted substantially at said distal end of said catheter; and

a doppler velocimeter connectable to said proximal end of said catheter.

23. The system of claim 21 wherein said doppler type detector includes

a doppler flo-wire comprising a proximal end and a distal end;

a doppler transducer mounted substantially at said distal end of said flo-wire; and

a doppler velocimeter connectable to said proximal end of said flo-wire.

24. A method of detecting an occlusion in a blood conduit of a hemodialysis patient including,

inserting a velocity sensing device into said conduit to provide a velocity signal representative of the velocity of blood flow in said conduit at the location of said device in said conduit and a position signal representative of said location,

moving said velocity sensing device through said conduit,

and sensing a significant change in said velocity signal and the position signal when said significant change occurs to provide an indication of the location of an occlusion in said blood conduit.

25. A method of detecting an occlusion in a blood conduit of a hemodialysis patient in accordance with claim 24 and further including,

inserting a dialysis needle into a blood vessel of said patient,

and inserting said velocity sensing device into said conduit through said dialysis needle.

26. Apparatus for detecting an occlusion in a blood conduit of a hemodialysis patient comprising,

a velocity sensing device in said conduit constructed and arranged to provide a velocity signal representative of the velocity of blood flow in said conduit at the location of said device in said conduit and a position signal representative of said location,

said velocity sensing device being movable through said conduit,

and a detector constructed and arranged to sense a significant change in said velocity signal and the position signal when said significant change occurs to provide an indication of the location of an occlusion in said blood conduit.

27. Apparatus for detecting an occlusion in a blood conduit of a hemodialysis patient in accordance with claim 26 and further comprising,

a dialysis needle in a blood vessel of said patient,

and a flexible lead connected to said velocity sensing device through said dialysis needle constructed and arranged to allow positioning of said device in said conduit from outside said patient.

28. A method of detecting an occlusion in a blood conduit of a hemodialysis patient comprising the steps of:

locating a section of blood flow conduit having a zone of a known cross-sectional area;

substantially all blood passing through said zone also flowing in the examined blood conduit;

measuring a velocity of the blood flow in said zone;

measuring a velocity of the blood flow in a region of the examined blood conduit; and

determining a cross-sectional area of said region based on said velocities.

29. The method of claim 28 wherein said measuring velocity includes making a doppler type measurement.

30. The method of claim 29 wherein said doppler type measurement comprises

introducing into said blood conduit a doppler transducer located substantially at the distal end of a flo-wire;

moving said doppler transducer to said region;

measuring a velocity of blood flow in said region;

moving said doppler transducer to said zone; and

measuring a velocity of blood flow in said zone.

31. The method of claim 30 further comprising controlling the orientation of said doppler transducer relative to the measured blood flow to achieve reliable velocity measurements.

32. The method of claim 30 wherein said velocity is a phasic velocity.

33. The method of claim 30 wherein said velocity is a mean velocity averaged over at least one heart beat.

34. The method of claim 30 further comprising:

moving said doppler transducer to a second region of said blood conduit;

measuring a velocity of blood flow in said second region; and

determining cross-sectional area of said second region based on said measured velocities.

35. The method of claim 29 wherein said velocity is a phasic velocity.

36. The method of claim 29 wherein said velocity is a mean velocity averaged over at least one heart beat.

37. The method of claim 29 wherein said doppler type measurement is repeated to monitor time dependence of said determined cross-sectional area.

38. The method of claim 29 wherein said blood conduit is a vein receiving blood from a surgically created shunt that bypasses flow directly from an artery to said vein.

39. The method of claim 29 wherein said blood conduit is an artery supplying blood to a surgically created shunt that bypasses flow directly from an artery to said vein.

40. A system for detecting a stenosis in a blood conduit of a hemodialysis patient comprising:

a detector constructed and arranged to provide velocity signals representative of velocity of the blood flow;

a blood flow conduit having a zone of a known cross-sectional area that intercepts substantially all blood flowing in said blood conduit; and

a processor constructed and arranged to receive velocity signals from said detector and provide an area signal representative of a cross-sectional area of a region of said blood conduit.

41. The system of claim 40 wherein said detector is a doppler flowmeter.

42. The system of claim 41 wherein said doppler flowmeter is an ultrasonic pulsed doppler flowmeter.

43. The system of claim 40 wherein said blood flow conduit is a part of a shunt constructed and arranged to connect a selected vein and a selected artery.

44. The system of claim 42 wherein said ultrasonic pulsed doppler flowmeter includes a doppler catheter having distal and proximal ends with a doppler transducer substantially at said distal end and a doppler velocimeter connected to said proximal end.

45. The system of claim 40 further comprising a display, connected to said processor to receive said area signal, constructed and arranged to display the area signals for each region of said blood conduit.