Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation

• US 5,690,681 A
• Filed: 03/29/1996
• Issued: 11/25/1997
• Est. Priority Date: 03/29/1996
• Status: Expired due to Term

• Current Assignee: Purdue Research Foundation (Purdue University)
• Original Assignee: Purdue Research Foundation (Purdue University)
• Inventors: Elabbady, Tarek, Geddes, Leslie A., Schoenlein, William E., Bourland, Joe D., Waninger, Matthew
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/624,109
• Time in Patent Office: 606 Days
• Field of Search: 607/4, 607/5, 607/9, 607/2, 607/44, 128/702, 128/703, 128/705
• US Class Current: 607/2
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

A closed-loop variable frequency vagal stimulation apparatus for control of ventricular rate during atrial fibrillation. In one embodiment the apparatus includes a stimulator applied to the left vagus nerve and a proportional controller programmed to automatically and continuously adjust the vagal stimulation frequency proportionally as a function of the difference between actual and desired ventricular excitation rates. In a second embodiment the apparatus includes a vagal nerve stimulator and a controller which automatically adjusts the vagal stimulation frequency as a function of the difference between ventricular excitation rate and arterial pulse rate in order to eliminate or minimize pulse deficit.

Claims

1. An apparatus for automatically controlling ventricular rate by vagal stimulation to minimize pulse deficit during atrial fibrillation, comprising:

stimulating means for stimulating a vagal nerve at a variable stimulation frequency;

means for detecting a ventricular excitation rate;

means for detecting an arterial pulse rate;

processing means for comparing said ventricular excitation rate and said arterial pulse rate and automatically adjusting said vagal stimulation frequency as a function of the difference between said ventricular excitation rate and said arterial pulse rate.

2. The apparatus of claim 1, wherein said processing means includes means for adjusting the vagal stimulation frequency as a function of the ratio of said ventricular excitation rate to said arterial pulse rate.

3. The apparatus of claim 2, wherein said processing means increases said vagal stimulation frequency at predetermined intervals until said pulse deficit is substantially eliminated.

4. The apparatus of claim 3, further comprising means for enabling generation of stimulating pulses only in the presence of atrial fibrillation.

5. The apparatus of claim 3, in which the predetermined interval is in the range of approximately one to ten minutes.