Gastro-intestinal pacemaker having phased multi-point stimulation

• US 5,690,691 A
• Filed: 05/08/1996
• Issued: 11/25/1997
• Est. Priority Date: 05/08/1996
• Status: Expired due to Term

• Current Assignee: University of Virginia Patent Foundation (University of Virginia)
• Original Assignee: The Center For Innovative Technology
• Inventors: Williams, Ronald, Lin, Zhiyue, Chen, Jian Dez, Tillack, Jonathan, McCallum, Richard W., Ross, Robert
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US08/646,959
• Time in Patent Office: 566 Days
• Field of Search: 607/2, 607/40, 607/72, 607/116, 607/133, 607/148, 600/29, 600/30
• US Class Current: 607/40
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control

Abstract

A portable or implantable gastric pacemaker includes multiple electrodes that are positionable on the inner or outer surface of an organ in the gastro-intestinal tract and which are individually programmed to deliver a phased electrical stimulation to pace peristaltic movement of material through the GI tract. The pacemaker will accommodate variations in pulse amplitudes, pulse durations, pulse periods, and relative pulse phasing among the electrodes. Computer control can be used to adjust and vary all stimulation parameters delivered by the electrodes to achieve effective treatment and re-training of an organ for natural pacing. The pacemaker can be programmed with parameters to enhance or accelerate peristaltic movement through the gastric tract or to attenuate the peristaltic movement to treat such conditions eating disorders or diarrhea.

Claims

1. A method for electrically stimulating at least one organ in the gastro-intestinal tract for peristaltic movement, comprising the steps of:

connecting a plurality of electrodes to at least one organ in the gastro-intestinal tract of a patient along a peristaltic flow path, each of said plurality of electrodes being connected at a different location along said peristaltic flow path; and

providing electrical pulses to said organ from each one of said plurality of electrodes, said electrical pulsed provided by said plurality of electrodes being in a phased relationship according to a desired peristaltic flow through said at least one organ in said gastrointestinal tract.

2. The method of claim 1 further comprising the step of independently regulating a pulse amplitude, a pulse timing, and a pulse duration for said electrical pulses for each one of said plurality of electrodes.

3. A method for electrically stimulating an organ as recited in claim 2 wherein said organ is a stomach and further comprising the step of selecting a pulse amplitude in the range of 0.1 to 10 mA and a pulse duration in the range of 10 to 1000 ms for at least one electrode of said plurality of electrodes.

4. A method for electrically stimulating an organ as recited in claim 1 wherein said organ is a stomach and further comprising the step of selecting a pulse frequency of 1.5 to 4 cycles per minute for each electrode in said plurality of electrodes with a selected phase offset between adjacent electrodes.

5. A method for electrically stimulating an organ as recited in claim 1 wherein said organ is a small intestine and further comprising the step of selecting a pulse frequency of 9 to 12.5 cycles per minute for each electrode in said plurality of electrodes with a selected phase offset between adjacent electrodes.

6. The method of claim 1 further comprising the steps of:

locating said plurality of electrodes on said organ with at least a first electrode being relatively closer to a distal end of said gastrointestinal tract than a second electrode and said second electrode being relatively more forward in said gastrointestinal tract than said first electrode; and

developing a phased pulse regimentation of said organ which progresses from said first electrode to said second electrode.

7. The method of claim 6 wherein said second electrode provides a relatively higher amplitude pulse stimulation to said organ than said first electrode.

8. The method of claim 1 further comprising the steps of:

locating said plurality of electrodes on said organ with at least a first electrode being relatively closer to a distal end of said gastrointestinal tract than a second electrode and said second electrode being relatively more forward in said gastrointestinal tract than said first electrode; and

developing a phased pulse regimentation of said organ which progresses from said second electrode to said first electrode.

9. The method of claim 8 wherein said second electrode provides a relatively higher amplitude pulse stimulation to said organ than said first electrode.

10. A gastric pacemaker for controlling the peristaltic pace of digestive organs, comprising:

a plurality of stimulation electrodes sequentially positionable on at least one digestive organ along a peristaltic flow path;

controller for controlling electrical pulse parameters for each of said plurality of stimulation electrodes in a phased relationship according to a desired peristaltic flow; and

circuitry for providing electrical pulses to each of said plurality of stimulation electrodes in accordance with said phased relationship.

11. A gastric pacemaker as recited in claim 10 further comprising a sensor electrode connectable to said digestive organ for sensing a response of said organ to an electrical pulse stimulation.

12. A gastric pacemaker as recited in claim 10 wherein at least one of said plurality of stimulation electrodes also functions as a sensing electrode for sensing a response of said organ to an electrical pulse.