×

Systems and methods for on line collection of cellular blood components that assure donor comfort

  • US 5,690,835 A
  • Filed: 09/24/1996
  • Issued: 11/25/1997
  • Est. Priority Date: 12/23/1991
  • Status: Expired due to Fees
First Claim
Patent Images

1. A blood processing system for obtaining during a processing period a cellular-rich concentrate from an anticoagulated cellular suspension conveyed from donor, while returning a cellular-poor component containing anticoagulant to the donor, without significant adverse anticoagulant-related donor reactions, comprisinga supply path including a supply pump to convey a cellular blood suspension including plasma from the donor,a source of anticoagulant,a branch path communicating with the supply path and the source of anticoagulant to add anticoagulant to the cellular blood suspension conveyed by the supply path in an added anticoagulant-to-cellular suspension volume ratio,a separation device communicating with the supply path to receive the anticoagulant-containing cellular blood suspension and to separate the anticoagulant-containing cellular blood suspension into a cellular-rich concentrate having a first plasma and anticoagulant volume and a cellular-poor component having a second plasma and anticoagulant volume, the second plasma and anticoagulant volume being greater than the first plasma and anticoagulant volume,a return path communicating with the separation device, including a return pump to convey the cellular-poor component from the separation device to the donor,a collection container,a collection path communicating with the return path and the collection container, including a retention pump to divert a portion of the cellular-poor component away from the donor for retention in the collection container while a remaining portion of cellular-poor component is conveyed to the donor in the return path, anda processing controller includingan input for receiving operating parameters including a portion of cellular-poor component to be diverted by the retention pump during the processing period, a volume of cellular-rich component to be collected during the processing period, and the added anticoagulant-to-cellular suspension volume ratio,an input for receiving physiological parameters of the donor including donor body weight, volume of cellular component present per unit volume of cellular blood suspension conveyed from the donor, and a physiological infusion rate of anticoagulant physiologically tolerated by the donor without significant adverse reactions, taking donor body weight into account,a processor that (i) derives an operative anticoagulant infusion rate based upon the operating parameters and the physiological parameters, (ii) compares the operative infusion rate to the physiological infusion rate, and (iii) generates a first control signal when the operative infusion rate is equal to or less than the physiological infusion rate and a second control signal when the operative infusion rate exceeds the physiological infusion rate, andan output coupled to the supply pump, the return pump, and the retention pump and being responsive to the first control signal to operate the supply, return, or retention pumps to achieve the operating parameters and being responsive to the second control signal to adjust at least one of the operating parameters, except the added anticoagulant-to-cellular suspension volume ratio, to lower the operative anticoagulant infusion rate to be equal to or below the physiological infusion rate.

View all claims
  • 0 Assignments
Timeline View
Assignment View
    ×
    ×