Implantable system for delivery of fluid-sensitive agents to animals
First Claim
1. A device for delivering a beneficial agent to a fluid environment of use, the device comprising:
- a) a housing comprising a fluid impermeable wall section, the housing containing the beneficial agent;
b) an exit passageway for fluidly connecting the housing interior to the environment of use;
c) an energy source for increasing pressure within the housing when the device is in the environment of use;
d) a sealing material, adjacent the exit passageway, the material being effective to seal the exit passageway before the housing is pressurized, at least a portion of the material being expelled through the passageway after the housing is pressurized, thereby opening the exit passageway, thereafter allowing continuous release of a therapeutically effective amount of beneficial agent during the entire time of delivery.
1 Assignment
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Accused Products
Abstract
A delivery system (10) is disclosed for delivering a fluid-sensitive beneficial agent (7) such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. An exit passageway is provided for delivering the beneficial agent an interior compartment (18) to the animal. The exit passageway is sealed with a wax seal (30) which is expelled through the passageway (13) as the internal pressure within the device (10) reaches a predetermined "bursting" pressure. The passageway (13) is preferably sized to compensate for slight variations in the efflux of the beneficial agent and to maintaining a sufficient volumetric outflow rate of beneficial agent in order to minimize influx of biological fluids from the external environment back into the device once the seal (30) is expelled.
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Citations
20 Claims
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1. A device for delivering a beneficial agent to a fluid environment of use, the device comprising:
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a) a housing comprising a fluid impermeable wall section, the housing containing the beneficial agent; b) an exit passageway for fluidly connecting the housing interior to the environment of use; c) an energy source for increasing pressure within the housing when the device is in the environment of use; d) a sealing material, adjacent the exit passageway, the material being effective to seal the exit passageway before the housing is pressurized, at least a portion of the material being expelled through the passageway after the housing is pressurized, thereby opening the exit passageway, thereafter allowing continuous release of a therapeutically effective amount of beneficial agent during the entire time of delivery. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification