Diagnostic tomographic laser imaging apparatus

• US 5,692,511 A
• Filed: 06/07/1995
• Issued: 12/02/1997
• Est. Priority Date: 06/07/1995
• Status: Expired due to Term

• Current Assignee: Richard J. Grable
• Original Assignee: Richard J. Grable
• Inventors: Grable, Richard J.
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): SHAW, SHAWNA JEANNINE
• Application Number:
  US08/484,904
• Time in Patent Office: 909 Days
• Field of Search: 128/633, 128/664, 128/665, 356/300, 356/446, 359/216, 359/217, 359/218, 359/223, 359/226, 378/37, 250/330, 250/332, 250/334
• US Class Current: 600/425
• CPC Class Codes: A61B 5/0091 for mammography
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence

Abstract

A laser imaging apparatus comprises a platform for supporting a female patient in front-down, prone position, including an opening permitting a breast of the patient to be vertically pendant below the surface of the platform; scanning mechanism including a multi-faceted mirror adjacent the underside of the platform, the mirror being rotated about its own axis and orbited around the pendent breast; a source of coherent near infrared narrow light pulses operably directed to the multi-faceted mirror; optical reflectors directing the light pulses onto the facets of the mirror from a point spaced from the platform for reflection in a series of horizontal fan shaped beams through a breast pendent below the platform; photodetectors operably disposed to detect the light pulses after passing through the breast; circuit for deriving voltages proportional to the intensity of the received pulses; and computer programmed for storing and displaying images of tissue in the breast derived from the voltages.

Claims

1. A method of providing imaging of humanoid breast tissue, comprising the steps of:

a) supporting a patient in face-down, prone position on a horizontal surface with a breast vertically pendent through an opening in said surface;

b) directing a succession of narrow coherent near infrared light pulses through said breast in a horizontal pattern from a plurality of positions completely surrounding said breast;

c) repeating said step b) in a plurality of closely vertically spaced horizontal planes until the entire breast has been scanned;

d) detecting said light pulses after passage through said breast tissue; and

e) deriving images of the breast tissue from said detected light pulses by computed tomography reconstruction.

2. A method as in claim 1, wherein said step b) of directing includes the step of orbiting said light pulses around said breast.

3. A method as in claim 1, and further comprising the step of directing said light pulses in a fan-shaped beam from each of said plurality of positions.

4. A method as in claim 1, wherein said step b) of directing is implemented with a rotating multifaceted mirror.

5. A method as in claim 1, wherein said step d) of detecting is implemented by avalanche photodiodes having response curve with a leading edge component.

6. A method as in claim 5, and further comprising the step of sampling only the leading edge component of the response curve of said avalanche photodiodes.

7. A scanning chamber for use in scanning human tissue, comprising:

a) a frame;

b) a rotatable plate supported by said frame, said plate including an opening for permitting the human tissue to be disposed in said opening;

c) a source of laser beam for passing through the tissue, said source being carried by said plate such that said source makes a complete orbit around said opening when said plate is rotated one complete revolution;

d) photodetectors disposed in a circle on said frame adapted to detect said source of laser beam after passage through the tissue; and

e) bearing assembly adapted to rotatably support said plate from said frame, said bearing assembly including an outer race secured to an opening on said frame, and an inner race secured to said plate.

8. A scanning chamber as in claim 7, wherein:

a) said frame is adapted for stepping said source of laser beam and said photodetectors vertically downwardly in small increments.

9. A scanning chamber as in claim 7, wherein:

a) said source of laser beam has light pulses in the order of 100 femtoseconds in width and a wavelength in the order of 850 nanometers.

10. A scanning chamber as in claim 7, wherein:

a) said source of laser beam includes a titanium sapphire laser; and

b) an argon ion laser adapted to pump said titanium sapphire laser.

11. A scanning chamber as in claim 7, wherein:

a) said photodetectors includes avalanche photodiodes.

12. A scanning chamber as in claim 7, and further comprising:

a) a rotating mirror adapted to direct said source of laser beam into a fan-shaped beam through the tissue.

13. A scanning chamber for use in scanning human tissue, comprising:

a) a frame;

b) a rotatable plate supported on said frame, said plate including an opening for permitting the human tissue to be suspended in said opening;

c) a source of laser beam for passing through the tissue, said source of laser beam being carried by said plate such that said source of laser beam makes a complete orbit around said opening when said plate is rotated one complete revolution;

d) photodetectors disposed in an arc on said plate adapted to detect said source of laser beam after passage through the tissue; and

e) bearing assembly adapted to rotatably support said plate from said frame, said bearing assembly including an outer race secured to an opening on said frame, and an inner race secured to said plate.

14. A scanning chamber as in claim 13, wherein:

a) said frame is movable vertically.

15. A scanning chamber as in claim 13, wherein:

a) said source of laser beam has light pulses in the order of 100 femtoseconds in width and a wavelength in the order of 850 nanometers.

16. A scanning chamber as in claim 13, wherein:

a) said source of laser beam includes a titanium sapphire laser; and

b) an argon ion laser adapted to pump said titanium sapphire laser.

17. A scanning chamber as in claim 13, wherein:

a) said photodetectors includes avalanche photodiodes.

18. A scanning chamber as in claim 13, and further comprising:

a) a rotating mirror adapted to direct said laser beam into a fan-shaped beam through the tissue.

19. A scanning chamber as in claim 13, and further comprising:

a) drive screws operably associated with said frame such that rotation of said drive screws are effective to lower or raise said frame.

20. A laser imaging apparatus, comprising:

a) a scanning chamber including a source of laser beam for passing through a tissue and at least one photodetector adapted to respond to the laser beam exiting the tissue, said at least one photodetector having a response curve with a leading edge component;

b) a time-gate switch circuit for sampling said leading edge component of said response curve for said at least one photodetector; and

c) a computer programmed to generate an image of the scanned tissue from the sampled leading edge component of said response curve.

21. A laser imaging apparatus as in claim 20, and further comprising:

c) a current-to-voltage conversion circuit connected to said at least one photodetector for converting the sampled leading edge component of said response curve current to a voltage.

22. A laser imaging apparatus as in claim 21, and further comprising:

a) said current-to-voltage conversion circuit includes an operational amplifier circuit.

23. A laser imaging apparatus as in claim 21, and further comprising:

a) said current-to-voltage conversion circuit includes an integrator circuit.

24. A laser imaging apparatus as in claim 21, and further comprising:

a) a clamp circuit adapted to protect said current-to-voltage conversion circuit from over-voltage.

25. A laser imaging apparatus as in claim 20, wherein:

a) said at least one photodetector includes an avalanche photodiode.

26. A laser imaging apparatus as in claim 20, wherein:

a) said time-gate switch includes a Schottkey diode operably connected to said at least one photodetector.

27. A laser imaging apparatus as in claim 20, wherein:

a) said source of laser beam includes near infrared laser pulses.

28. A laser imaging apparatus as in claim 20, and further comprising:

a) a rotating mirror adapted to direct said source of laser beam into a fan-shaped beam through the tissue.