Solid state fluid delivery system

• US 5,693,016 A
• Filed: 11/08/1995
• Issued: 12/02/1997
• Est. Priority Date: 11/08/1995
• Status: Expired due to Term

• Current Assignee: MicroDose Therapeutx, Inc. (Teva Pharmaceutical Industries Limited)
• Original Assignee: Microdose Technologies Inc. (Teva Pharmaceutical Industries, Ltd.)
• Inventors: Fleming, Scott, Gumaste, Anand V., Abrams, Andrew L.
• Primary Examiner(s): Rimell, Sam
• Assistant Examiner(s): Yeh, Luke
• Application Number:
  US08/555,225
• Time in Patent Office: 755 Days
• Field of Search: 417/412, 417/413.2, 417/413.1, 417/474, 604/68, 604/892.1, 604/131, 604/132, 604/151, 604/153
• US Class Current: 604/131
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

An apparatus and method are disclosed that utilize piezoelectric materials as part of a delivery system capable of the rapidly repetitive dispensing of a fluid to an intended target site. In a particular embodiment, the apparatus contemplates a needleless injection system which comprises a second housing structure, a plurality of piezoelectric elements which are stacked in a layered fashion within the second housing structure, electronic circuitry disposed proximate the second housing structure and hence the layered stack of piezoelectric elements, and a first housing structure containing a fluid reservoir operatively connected to the second housing structure so as to allow fluid contained with the fluid reservoir to communicate with the layered stack of piezoelectric elements. The layered stack of piezoelectric elements has at least one common aperture formed therein which extends therethrough.

Claims

1. An apparatus for the rapid and repeatable delivery of small quantities of a fluid to an intended target, comprising:

A. at least one first housing having walls defining a dispensing chamber for said fluid, and at least one nozzle element defined in one of said walls for the discharge of said fluid; and

B. at least one second housing communicating with said first housing, said second housing comprising pump means comprising a plurality of piezoelectric elements disposed in a stacked arrangement adjacent one another, each of said piezoelectric elements having at least one opening therein, said openings being journaled within each of said piezoelectric elements in axial alignment as between adjacent said piezoelectric elements, said axially aligned stacked piezoelectric elements being pliably sealed to one another whereby to define a non-porous chamber for receiving and holding a predetermined volume of said fluid, said plurality of piezoelectric elements being adapted for sequential excitation to simulate a peristaltic motion whereby to receive a predetermined volume of said fluid from said dispensing chamber, and thereafter to eject the same through said at least one nozzle element toward said target; and

actuation means for exciting said pump means.

2. The apparatus according to claim 1, wherein said plurality of piezoelectric elements comprise at least two piezoelectric elements stacked adjacent each other.

3. The apparatus according to claim 1, wherein said plurality of piezoelectric elements comprise three piezoelectric elements stacked adjacent each other.

4. The apparatus according to claim 1, wherein said first housing and said second housing are integral with each other, and may be disposable as a unit.

5. The apparatus according to claim 1, wherein said first housing is disposable.

6. The apparatus according to claim 1, wherein said apparatus is portable and said actuation means comprises a battery.

7. The apparatus according to claim 1, wherein plural nozzle elements are defined.

8. The apparatus according to claim 1, wherein plural openings are defined in each of said piezoelectric elements.

9. A needleless injection system that utilizes layered piezoelectric materials to forcibly introducing fluid medication through the skin of a patient, said system comprising:

a second housing having a first opening and a second opening formed the therein, a plurality of piezoelectric elements, said plurality of piezoelectric elements being stacked in a layered fashion and pliably sealed to one another within said second housing between said first opening and said second opening, each of said plurality of piezoelectric elements having an aperture formed therein, each said aperture being aligned so as to form a common aperture extending through said layered stack of piezoelectric elements from said first opening to said second opening whereby to define a chamber for receiving and holding a predetermined volume of said fluid;

a first housing comprising a fluid reservoir, said fluid reservoir being operatively connected to said first opening of said second housing so as to allow fluid medication contained within said fluid reservoir to communicate with said layered stack of piezoelectric elements; and

electronic circuitry, said electronic circuitry being electrically connected to said layered stack of piezoelectric elements so as to allow each of said plurality of piezoelectric elements to be individually excited and the size of each of said aperture to be individually controlled, thereby allowing said layered stack of piezoelectric elements to be utilized as a pump wherein fluid medication from said fluid reservoir may be forced into and out from each said aperture and ultimately be forcibly introduced through the skin of a patient.

10. The system according to claim 9, wherein said second housing, said first housing and said electronic circuitry are integral with each other.

11. The system according to claim 9, further comprising an interface connector between said fluid reservoir and said first opening of said second housing.

12. The system according to claim 10, wherein said interface connector comprises a luer-lock connector so as to allow quick and easy attachment and removal of said fluid reservoir from said second housing.

13. The system according to claim 9, further comprising securement means upon which said electronic circuitry and said fluid reservoir and through which said second housing and hence said layered stack of piezoelectric elements are mounted so as to allow said system to be easily removably attached to a patient.

14. The system according to claim 9, wherein said plurality of piezoelectric elements comprise at least two piezoelectric elements stacked in a layered fashion within said second housing between said first opening and said second opening.

15. The system according to claim 9, wherein each of said plurality of piezoelectric elements have a plurality of apertures formed therein, wherein each of said plurality apertures are aligned in groups so as to form a plurality of common apertures extending through said layered stack of piezoelectric elements from said first opening to said second opening.

16. The system according to claim 9, wherein said fluid reservoir includes electronically actuated means for forcing fluid medication therefrom.

17. The system according to claim 9, wherein said fluid reservoir may be fabricated of a collapsible material so as to allow fluid medication to be forced therefrom by external pressure.

18. A needleless injection method that utilizes layered piezoelectric materials to forcibly introduce fluid medication through the skin of a patient, said method comprising the steps of:

providing a second housing, having a first opening and a second opening formed therein;

stacking a plurality of piezoelectric elements in a layered fashion within said second housing between said first opening and said second opening, each of said plurality of piezoelectric elements being pliably sealed to one another, and each having an aperture formed therein, each said aperture being aligned so as to form a chamber for receiving and holding a predetermined volume of said fluid, extending through said layered stack of piezoelectric elements from said first opening to said second opening;

operatively connecting a first housing containing a fluid reservoir to said first opening of said second housing so as to allow fluid medication contained within said fluid reservoir to communicate with said layered stack of piezoelectric elements; and

individually exciting each of said plurality of piezoelectric elements so as to allow the size of each said aperture to be individually controlled, thereby allowing said layered stack of piezoelectric elements to be utilized as a pump wherein fluid medication from said fluid reservoir may be forced into and out from each said aperture and ultimately be forcibly introduced through the skin of a patient.