Apparatus and method of delivery of gas-supersaturated solutions to a delivery site
First Claim
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1. An apparatus for delivering a gas-supersaturated solution to a delivery site comprising:
- a hollow, gas-tight vessel;
a collapsible container of solution disposed within the vessel so that a space between the container and the vessel is provided;
a tubular member sealingly inserted into the vessel and the container, the tubular member being in communication with a supply of gas under pressure for driving the gas into the solution via the tubular member, thereby preparing gas-supersaturated solution within the container;
an inlet port provided in the vessel in communication with the space and the supply of gas for pressurizing the space;
an adjustable container exit valve in communication with the container, the container exit valve controlling the flow of undissolved gas from the container;
an adjustable space exit valve in communication with the vessel, the space exit valve capable of controlling the flow of gas from the space so that gas leaves the space at a higher rate than that at which gas is introduced into the solution;
a fluid control means having a gas-opened state which permits the gas to flow from the supply into the tubular member and a gas-closed state which precludes the gas from flowing from the supply to the tubular member by the fluid control means and the gas-supersaturated solution may flow from the tubular member to the delivery site without bubble formation.
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Abstract
An apparatus (10) and method for delivering an oxygen-supersaturated physiologic solution (12) into a lumen (14) of a blood vessel (16) to replace arterial blood beyond an angioplasty catheter (18) during clinical angioplasty without bubble formation.
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Citations
32 Claims
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1. An apparatus for delivering a gas-supersaturated solution to a delivery site comprising:
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a hollow, gas-tight vessel; a collapsible container of solution disposed within the vessel so that a space between the container and the vessel is provided; a tubular member sealingly inserted into the vessel and the container, the tubular member being in communication with a supply of gas under pressure for driving the gas into the solution via the tubular member, thereby preparing gas-supersaturated solution within the container; an inlet port provided in the vessel in communication with the space and the supply of gas for pressurizing the space; an adjustable container exit valve in communication with the container, the container exit valve controlling the flow of undissolved gas from the container; an adjustable space exit valve in communication with the vessel, the space exit valve capable of controlling the flow of gas from the space so that gas leaves the space at a higher rate than that at which gas is introduced into the solution; a fluid control means having a gas-opened state which permits the gas to flow from the supply into the tubular member and a gas-closed state which precludes the gas from flowing from the supply to the tubular member by the fluid control means and the gas-supersaturated solution may flow from the tubular member to the delivery site without bubble formation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. An apparatus for producing and delivering a gas-enriched solution comprising:
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a pressurizable housing having an input and an output; a collapsible container containing a solution and disposed within the housing, wherein the housing and the container forms a space therebetween, said space containing a first pressurized gas; an input tubular member in communication with the housing input, wherein the input tubular member extends into the solution for delivering a second pressurized gas to the solution, thereby preparing a gas-enriched solution within the container; and an output tubular member in communication with the housing output, wherein the output tubular member extends into the container for allowing undissolved gas to exit from the container and wherein the output tubular member further extends into the solution for delivering the gas-enriched solution. - View Dependent Claims (21, 22, 23, 24)
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25. A method for delivering a gas-supersaturated solution to a delivery site, comprising:
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placing a collapsible container of a solution within a hollow, gas-tight vessel so that a space between the container and the vessel is provided; locating a tubular member within the container, the tubular member being in communication with a supply of gas under pressure; dissolving the gas into the solution under pressure to prepare the gas-supersaturated solution within the container; controlling respective gas flow rates into the solution and from the space so that the gas leaves the space at a higher rate than that at which gas is introduced into the solution; and delivering the gas-supersaturated solution to the delivery site. - View Dependent Claims (26, 27, 28, 29)
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30. A method for creating a gas-enriched solution and delivering the solution to a delivery site, comprising the steps of:
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providing a collapsible container containing a solution in a housing with an input and an output such that a space is created between the container and the housing, wherein the space contains a gas; providing an output tubular member within the container and in communication with the housing output and extending at least a portion of the output tubular member into the solution; pressurizing the gas in the space; delivering a pressurized gas into the solution through the input tubular member thereby creating the gas-enriched solution; and delivering the gas-enriched solution to the delivery site through the housing output via the output tubular member. - View Dependent Claims (31, 32)
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Specification