Enhancement of ultrasound thrombolysis

• US 5,695,460 A
• Filed: 05/15/1995
• Issued: 12/09/1997
• Est. Priority Date: 09/09/1994
• Status: Expired due to Fees

• Current Assignee: TransOn LLC
• Original Assignee: Coraje, Inc.
• Inventors: Siegel, Robert J., Carter, Robert E.
• Primary Examiner(s): Bockelman, Mark
• Assistant Examiner(s): SMITH, CHALIN A
• Application Number:
  US08/441,127
• Time in Patent Office: 939 Days
• Field of Search: 604/19-22, 604/49, 604/52, 604/53, 128/653.4, 128/660.2, 128/660.01, 601/2-3
• US Class Current: 604/21
• CPC Class Codes: A61B 17/22004 using mechanical vibrations, e.g. ultrasonic shock waves A61B17/225 takes precedence
• CPC Class Codes: A61B 17/22012 in direct contact with, or very close to, the obstruction or concrement for removing obstructions in blood vessels by laser A61B18/245
• CPC Class Codes: A61B 2017/22084 stone- or thrombus-dissolving
• CPC Class Codes: A61B 2017/22088 ultrasound absorbing, drug activated by ultrasound
• CPC Class Codes: A61B 2017/22089 Gas-bubbles
• CPC Class Codes: A61B 2090/3925 ultrasonic
• CPC Class Codes: A61B 2090/3933 Liquid markers
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

Apparatus and methods are provided for utilizing a combination of ultrasonic energy and an echo contrast agent containing microbubbles, for substantially dissolving blood clots or other vascular obstructions. One embodiment of the present invention utilizes a selected dose of thrombolytic agent in combination with an echo contrast agent, for enhancing the thrombolytic action of a thrombolytic agent and removing a thrombosis from a vascular system in less time than the time required by activity of the selected dose of thrombolytic agent without the ultrasonic radiation of the thrombosis.

Claims

1. A method for removing a thrombosis, said method comprising the steps of:

(a) radiating a thrombosis, disposed in a vessel within a body, with ultrasound in order to effect removal of the thrombosis by dissolution thereof, said ultrasound being introduced at a frequency of less than about 100 kHz; and

(b) introducing a selected dose of an echo contrast agent proximate the thrombosis in order to enhance the effectiveness of the ultrasound in removing the thrombosis by dissolution thereof.

2. The method according to claim 1 wherein the ultrasound is applied transcutaneously.

3. The method according to claim 1 wherein the ultrasound is applied intravascularly.

4. The method according to claim 1 wherein the ultrasound is introduced at a frequency of between about 24 kHz and about 53 kHz.

5. The method according to claim 1 wherein the ultrasound is introduced at a frequency of between about 24 kHz and about 53 kHz.

6. The method according to claim 1 wherein the echo contrast agent is comprised of a microbubble medium.

7. The method according to claim 6 wherein the microbubble medium is comprised of a medium selected from the group consisting of free gas bubbles, stabilized gas bubbles, colloidal suspensions, emulsions, and aqueous solutions.

8. The method according to claim 7 wherein the microbubble medium is a colloidal suspension comprising dodecafluropentane.

9. The method according to claim 7 wherein the microbubble medium is an aqueous solution comprised of sonicated albumin.

10. A method for enhancing thrombolytic action of a thrombolytic agent, said method comprising the steps of:

(a) radiating a thrombosis, disposed in a vessel within a body, with ultrasound in order to effect removal of the thrombosis, said ultrasound having a frequency of less than about 100 kHz;

(b) introducing a selected dose of a thrombolytic agent proximate the thrombosis; and

(c) introducing a selected dose of an echo contrast agent proximate the thrombosis in order to enhance the effectiveness of both the ultrasound and the thrombolytic agent in removing the thrombosis.

11. The method according to claim 10 wherein the ultrasound is applied transcutaneously.

12. The method according to claim 10 wherein ultrasound is applied intravascularly.

13. The method according to claim 10 wherein streptokinase is introduced as the thrombolytic agent.

14. The method according to claim 10 wherein the echo contrast agent is comprised of a microbubble medium.

15. The method according to claim 14 wherein the microbubble medium is comprised of a medium selected from the group consisting of free gas bubbles, stabilized gas bubbles, colloidal suspensions, emulsions, and aqueous solutions.

16. The method according to claim 15 wherein the microbubble medium is a colloidal suspension comprising dodecafluropentane.

17. The method according to claim 15 wherein the microbubble medium is an aqueous solution comprising sonicated albumin.

18. Apparatus for removal of a cardiovascular blockage, said apparatus comprising, in combination:

ultrasonic means for radiating a cardiovascular blockage with ultrasound, having a frequency of less than about 100 kHz; and

means for introducing a selected dose of an echo contrast agent proximate the cardiovascular blockage in order to enhance the effect of the ultrasound in removing the cardiovascular blockage.

19. The apparatus of claim 18 wherein the echo contrast agent is a microbubble medium selected from the group consisting of free gas bubbles, stabilized gas bubbles, colloidal suspensions, emulsions, and aqueous solutions.