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Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies

  • US 5,697,373 A
  • Filed: 03/14/1995
  • Issued: 12/16/1997
  • Est. Priority Date: 03/14/1995
  • Status: Expired due to Term
First Claim
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1. A method of detecting and quantifying tissue abnormality in a tissue sample, comprising:

  • illuminating said tissue sample with a first electromagnetic radiation wavelength selected to cause said tissue sample to produce a fluorescence intensity spectrum indicative of tissue abnormality;

    detecting a first fluorescence intensity spectrum emitted from said tissue sample as a result of illumination with said first wavelength;

    illuminating said tissue sample with a second electromagnetic radiation wavelength selected to cause said tissue sample to produce a fluorescence intensity spectrum indicative of a degree of tissue abnormality;

    detecting a second fluorescence intensity spectrum emitted from said tissue sample as a result of illumination with said second wavelength;

    calculating from said first fluorescence intensity spectrum, a probability that said tissue sample is normal or abnormal; and

    calculating from said second fluorescence intensity spectrum a degree of abnormality of said tissue sample.

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