Method and apparatus utilizing heart sounds for determining pressures associated with the left atrium

• US 5,697,375 A
• Filed: 01/24/1995
• Issued: 12/16/1997
• Est. Priority Date: 09/18/1989
• Status: Expired due to Term

• Current Assignee: The Research Foundation for The State University of New York (State University of New York)
• Original Assignee: The Research Foundation for The State University of New York (State University of New York)
• Inventors: Hickey, Donald D.
• Primary Examiner(s): Nasser, Robert L.
• Application Number:
  US08/377,466
• Time in Patent Office: 1,057 Days
• Field of Search: 128/672.3, 128/675, 128/687, 128/748, 128/774, 128/780, 128/668
• US Class Current: 600/486
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/037 Measuring oesophageal pressure
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis

Abstract

Non-invasive apparatus and method for obtaining a quantitative determination of mean left atrial transmural pressure or otherwise obtaining a quantitative determination of a left atrial pressure value. A balloon is inserted by means of a catheter into the esophagus and positioned adjacent the left atrium. The balloon is gradually inflated. A tracing of mean balloon pressure is obtained as the balloon is inflated. In addition, a tracing of balloon pressure on a steady baseline and with low frequency oscillations due to respiration filtered out is obtained whereby the tracing represents balloon pressure oscillations effected by left atrial pressure. In accordance with the oscillometric principle the mean balloon pressure is measured when the intensity of a sound wave, after its transmission through the balloon, is at a peak. This mean balloon pressure, after adjustment for the effect, if any, of heart weight, is indicative of approximate mean left atrial pressure. Mean left atrial transmural pressure may be determined by adjusting for the effects of heart weight and intrapleural pressure on mean pressure at peak sound intensity by subtracting therefrom the balloon pressure at which balloon volume begins to increase greatly relative to the increase in balloon pressure.

Claims

1. Apparatus for determining a mean pressure from a source within a body comprising a balloon positionable within the body adjacent the source, means for inflating said balloon, means for detecting and determining intensity of a sound wave from said source after the sound wave is transmitted through said balloon, and means for, determining the balloon pressure when the intensity of the sound wave is, after the sound wave is transmitted through said balloon, at a peak.

2. Apparatus according to claim 1 wherein said detecting and determining means comprises a microphone for receiving and providing an output of the sound wave after it is transmitted through said balloon.

3. Apparatus according to claim 2 wherein said microphone is disposed to be in pressure communication with said balloon, said microphone comprising means for equilibrating balloon pressure changes while preventing the sound wave intensity from significantly equilibrating.

4. Apparatus according to claim 3 wherein said microphone is a condenser microphone which has a pair of diaphragms acting as a capacitor, housing means for sound isolating one of said diaphragms, low pass filter means in said housing means for equilibrating balloon pressure changes, and means for equalizing pressure on both sides of said one diaphragm.

5. Apparatus according to claim 4 wherein said low pass filter means comprises a length of tubing connected to said housing to provide communication between the interior and exterior of said housing, said tubing selected to have a length and bore diameter which equilibrates balloon pressure changes while preventing the sound wave intensity from significantly equilibrating.

6. Apparatus according to claim 5 wherein said tubing is composed of a rigid material whereby to prevent penetration of sound through a wall of said tubing.

7. Apparatus according to claim 1 wherein said means for measuring the balloon pressure comprises means for measuring the mean balloon pressure when the intensity of a sound wave is, after the sound wave is transmitted through said balloon, at a peak.

8. Apparatus comprising a catheter which includes a balloon and is insertable into an esophagus for positioning said balloon adjacent the left atrium, means for inflating said balloon, means for detecting and determining intensity of heart sounds from the left atrium after the heart sounds are transmitted through said balloon, and means for determining the balloon pressure when the intensity of the heart sounds, after they are transmitted through said balloon, is at a peak.

9. Apparatus according to claim 8 wherein said balloon has an inflated diameter which is between about 0.8 and 1.5 cm.

10. Apparatus according to claim 8 further comprising means for adjusting the measured balloon pressure for the effect of heart weight.

11. Apparatus according to claim 8 wherein said means for measuring the balloon pressure comprises means for measuring the mean balloon pressure when the intensity of a sound wave is, after the sound wave is transmitted through said balloon, at a peak.

12. Apparatus according to claim 11 wherein said catheter includes means defining a balloon pressurization line and said microphone is disposed in pressure communication with said balloon pressurization line, said microphone comprising means for equilibrating balloon pressure changes while preventing the intensity of the heart sounds from significantly equilibrating.

13. Apparatus according to claim 12 wherein said microphone is a condenser microphone which has a pair of diaphragms acting as a capacitor, housing means for sound isolating one of said diaphragms, low pass filter means in said housing means for equilibrating balloon pressure changes, and means for equalizing pressure on both sides of said one diaphragm.

14. Apparatus according to claim 13 wherein said low pass filter means comprises a length of tubing connected to said housing to provide communication between the interior and exterior of said housing, said tubing selected to have a length and bore diameter which equilibrates balloon pressure changes while preventing the intensity of the heart sounds from significantly equilibrating.

15. Apparatus according to claim 14 wherein said tubing is composed of a rigid material whereby to prevent penetration of sound through a wall of said tubing.

16. Apparatus according to claim 8 wherein said detecting and determining means comprises a microphone for receiving and providing an output of the heart sounds after they are transmitted through said balloon.

17. A method of determining a mean pressure from a source within a body comprising the steps of:

a. positioning a balloon within the body adjacent the source;

(b) inflating the balloon; and

(c) determining intensity of a sound wave from the source after the sound wave is transmitted through the balloon, and determining the balloon pressure when the intensity of the sound wave is, after the sound wave is transmitted through the balloon, at a peak.

18. A method according to claim 17 comprising positioning the balloon between the source and a member such that the member acts as acts as an anvil for the source pressure acting on the balloon.

19. A method according to claim 17 comprising disposing a microphone having a pair of diaphragms acting as a capacitor and one of which is sound isolated in pressure communication with the balloon, and equilibrating balloon pressure changes acting on the diaphragms while preventing the sound wave intensity from significantly equilibrating.

20. A method according to claim 19 comprising connecting tubing to the housing to provide communication between the interior and exterior of the housing, and selecting the length and bore diameter of the tubing to equilibrate balloon pressure changes to the diaphragms while preventing the sound wave intensity from significantly equilibrating.

21. A method according to claim 20 further comprising selecting the tubing to be composed of a rigid material to prevent penetration of sound through a wall of the tubing.

22. A method of determining a mean pressure from a source within a body comprising the steps of:

a. positioning a balloon within the body adjacent the source;

b. inflating the balloon; and

c. determining intensity of a sound wave from the source after the sound wave is transmitted through the balloon, and determining the mean balloon pressure when the intensity of the sound wave is, after the sound wave is transmitted through the balloon, at a peak.

23. A method of determining mean left atrial pressure comprising the steps of:

a. inserting a catheter including a balloon into an esophagus of a subject;

b. positioning the balloon adjacent the left atrium;

c. inflating the balloon; and

d. determining intensity of heart sounds from the left atrium after the heart sounds are transmitted through the balloon, and determining the balloon pressure when the intensity of the heart sounds after they are transmitted through the balloon is at a peak.

24. A method according to claim 23 further comprising selecting the balloon to have an inflated diameter which is between about 0.8 and 1.5 cm.

25. A method according to claim 23 wherein the step of measuring the balloon pressure comprises measuring the mean balloon pressure when the intensity of heart sounds after they are transmitted through the balloon is at a peak.

26. A method according to claim 23 comprising disposing a microphone having a pair of diaphragms acting as a capacitor and one of which is sound isolated in pressure communication with the balloon, and equilibrating balloon pressure changes acting on the diaphragms while preventing the sound wave intensity from significantly equilibrating.

27. A method according to claim 26 comprising connecting tubing to the housing to provide communication between the interior and exterior of the housing, and selecting the length and bore diameter of the tubing to equilibrate balloon pressure changes to the diaphragms while preventing the sound wave intensity from significantly equilibrating.

28. A method according to claim 27 further comprising selecting the tubing to be composed of a rigid material to prevent penetration of sound through a wall of the tubing.

29. A method according to claim 23 further comprising adjusting the measured balloon pressure for the effect of heart weight.

30. A method according to claim 29 wherein the step of adjusting the measured balloon pressure comprises determining the difference between balloon pressures at which balloon volume begins to increase greatly relative to increase in balloon pressure while the balloon is inflated while adjacent the left atrium and while a balloon is inflated while at a distance of at least about 10 cm. from the heart respectively and subtracting said difference from the measured balloon pressure when the intensity of heart sound is at a peak.