Implantable stimulation and drug infusion techniques

• US 5,697,951 A
• Filed: 04/25/1996
• Issued: 12/16/1997
• Est. Priority Date: 04/25/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Harpstead, Stanley D., Otten, Lynn M., Prentice, Thomas R.
• Primary Examiner(s): Kamm, William L.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/637,362
• Time in Patent Office: 600 Days
• Field of Search: 607/3, 607/4, 607/33, 607/120, 604/890.1, 604/891.1, 604/20, 604/21, 604/51, 604/93, 604/114
• US Class Current: 607/3
• CPC Class Codes: A61N 1/306 Arrangements where at least part of the apparatus is introduced into the body
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals

Abstract

An implantable system for infusing a fluid agent and providing electrical stimulation without requiring an implanted pump or implanted source of electrical energy. An implantable housing is fitted with a percutaneous fill port that communicates with a reservoir to hold a fluid agent, such as a drug. An antenna located inside the housing receives radio frequency power signals from an outside antenna. A pulse generator outside the housing receives power and information from the radio frequency signals to produce stimulation pulses. The pulses and the fluid agent are both transported by a catheter to a site of application in the body. A connector allows the stimulation pulses and fluid agent to be transported from the housing to the catheter while maintaining electrical isolation between the stimulating pulses and the fluid agent.

Claims

1. An implantable system for infusing a fluid agent and providing electrical stimulation to a body using a source of fluid pressure and a source of electrical power both located external to said body, comprising:

an implantable housing defining a first surface and a second surface;

a percutaneous fill port located adjacent said first surface;

an antenna located inside said housing for receiving radio frequency power signals;

means located inside said housing and coupled to said antenna for generating stimulation pulses from said radio frequency power signals received by said antenna;

a catheter defining an outer surface, a proximal end, a distal end and a fluid lumen for transporting said fluid agent through said catheter, said catheter comprising at least one electrode for administering electrical stimulation to a predetermined portion of said body, at least one catheter conductor for transmitting said stimulation pulses to said at least one electrode and means for transporting said fluid agent from said fluid lumen to a predetermined portion of said body;

a reservoir located inside said housing and adapted to hold said fluid agent at a pressure maintained by a supply of said fluid agent admitted through said fill port for transmitting said fluid agent from said fluid lumen in the absence of a source of fluid pressure inside said housing; and

connector means for transmitting said stimulation pulses from said means for generating to said at least one catheter conductor and for transporting said fluid agent from said reservoir to said fluid lumen, whereby said fluid agent and said electrical stimulation are administered to said body in the absence of a source of fluid pressure or electrical power inside said housing.

2. A system, as claimed in claim 1 wherein said first surface is smaller than said second surface and wherein said antenna is located adjacent said second surface.

3. A system, as claimed in claim 2, wherein said reservoir is located between said antenna and said first surface.

4. A system, as claimed in claim 3, wherein said means for generating is located between said antenna and said reservoir.

5. A system, as claimed in claim 1, wherein said radio frequency power signals comprise data signals.

6. A system, as claimed in claim 1, wherein said means for generating is powered by said radio frequency power signals.

7. A system, as claimed in claim 1, wherein said catheter further comprises a second lumen for carrying said at least one catheter conductor, said second lumen being electrically isolated from said fluid lumen.

8. A system, as claimed in claim 7, wherein said second lumen is coaxial with said fluid lumen.

9. A system, as claimed in claim 1, wherein said means for transporting comprises a channel between said fluid lumen and said outer surface of said catheter.

10. A system, as claimed in claim 1, wherein said connector means comprises a connector block assembly for each of said at least one catheter conductor, each said connector block assembly comprising:

a block defining an opening;

a metal sleeve located inside said opening; and

a conductor coupled between said means for generating and said metal sleeve.

11. A system, as claimed in claim 10, wherein said catheter comprises a terminal coupled to each of said at least one cather conductor and extending through the outer surface of said catheter, each of said terminals being connected to said metal sleeve of one of said connector block assemblies.

12. A system, as claimed in claim 11, wherein said catheter further comprises a second lumen for carrying said at least one catheter conductor, said second lumen being electrically isolated from said fluid lumen and being located around said first lumen.

13. A system, as claimed in claim 12, wherein said connector means comprises a tube located inside said fluid lumen and extending through said opening of said connector block assembly for each of said at least one catheter conductor, said tube being coupled between said reservoir and said fluid lumen, whereby fluid is transported from said reservoir to said fluid lumen of said catheter while said stimulation pulses are being conducted to said at least one or more catheter conductor.

14. A system, as claimed in claim 1, and further comprising means for regulating the rate of flow of said fluid agent from said reservoir to said catheter.

15. A system, as claimed in claim 14, wherein said radio frequency power signals comprise flow regulating data signals for regulating the rate of flow of fluid agent from said reservoir to said catheter and wherein said means for generating said stimulation pulses further comprises means for controlling said means for regulating based on said flow regulating data signals.

16. A system, as claimed in claim 1, wherein said means located inside said housing and coupled to said antenna for generating stimulation pulses from said radio frequency power signals received by said antenna comprises a generator that is adapted to generate both stimulation pulses and control signals from said radio frequency power signals received by said antenna, and wherein said implantable system further comprises a valve responsive to said control signals and located intermediate said reservoir and said catheter for regulating a rate of flow of said fluid agent from said reservoir to said catheter.

17. An implantable system for infusing a fluid agent and providing electrical stimulation to a body, comprising:

an implantable housing defining a first surface and a second surface;

a percutaneous fill port located adjacent said first surface;

a reservoir located inside said housing for holding said fluid agent at a pressure maintained by a supply of said fluid agent admitted through said fill port;

an antenna located inside said housing for receiving radio frequency power signals;

means located inside said housing and coupled to said antenna for generating stimulation pulses from said radio frequency power signals received by said antenna;

a catheter defining an outer surface, a proximal end, a distal end, a fluid lumen for transporting said fluid agent through said catheter, and a second lumen electrically isolated from said fluid lumen and being located around said first lumen, said catheter comprising at least one electrode for administering electrical stimulation to a predetermined portion of a body, at least one catheter conductor carried in said second lumen for transmitting said stimulation pulses to said at least one electrode, a terminal coupled to each of said at least one catheter conductor and extending through said outer surface of said catheter, and means for transporting said fluid agent from said fluid lumen to a predetermined portion of a body; and

connector means for transmitting said stimulation pulses from said means for generating to said at least one catheter conductor and for transporting said fluid agent from said reservoir to said fluid lumen, said connector means comprising a connector block assembly for each of said at least one catheter conductor, each said connector block assembly comprising a block defining an opening, a metal sleeve located inside said opening and connected to said terminal of one of said at least one catheter conductor, and a conductor coupled between said means for generating and said metal sleeve, said connector means further comprising a tube located inside said fluid lumen and extending through said opening of said connector block assembly for each of said at least one catheter conductor, said tube being coupled between said reservoir and said fluid lumen, whereby fluid is transported from said reservoir to said fluid lumen of said catheter for administration to said body while said stimulation pulses are being conducted to said at least one catheter conductor, in the absence of a source of fluid pressure or electrical power inside said housing.