Bioprosthetic heart valves having high calcification resistance
First Claim
1. A calcification resistant bioprosthetic heart valve prepared by binding an anionic hydrophilic polymer derivative of sulfonated polyethylene oxide covalently to tissue selected from the group consisting of porcine aortic valve and bovine pericardium.
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Abstract
The specification describes an invention of calcification resistant bioprosthetic heart valves which can be used for a long term, and have good blood compatibility and in vivo stability, and have high calcification resistance. The bioprosthetic heart valves of the invention can be prepared by binding sulfonated polyethylene oxide (PEO) derivatives covalently to the tissue. The valves have an anionic effect equal to that of chondroitin sulfate, space filling effect, and blocking effect of the carboxyl group of collagen which has been known as one factor of the calcium deposition,. In particular, the present method has better advantages in view of calcification resistance than any other conventional methods, because it suppresses thrombosis and embolism and decreases incidence of infection.
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Citations
31 Claims
- 1. A calcification resistant bioprosthetic heart valve prepared by binding an anionic hydrophilic polymer derivative of sulfonated polyethylene oxide covalently to tissue selected from the group consisting of porcine aortic valve and bovine pericardium.
- 19. A method for preparing calcification resistant bioprosthetic heart valves which comprises binding an anionic hydrophilic polymer derivative of sulfonated polyethylene oxide covalently to tissue selected from the group consisting of porcine aortic valve and bovine pericardium.
Specification