Artificial filling and prosthetic material

• US 5,697,980 A
• Filed: 06/02/1995
• Issued: 12/16/1997
• Est. Priority Date: 04/19/1991
• Status: Expired due to Fees

• Current Assignee: Hirosi Machino, Kazusi Matuura, Kunio Niijima, Sadakatsu Yanagisawa, Sugio Otani, Toru Fuse
• Original Assignee: Hirosi Machino, Kazusi Matuura, Kunio Niijima, Sadakatsu Yanagisawa, Sugio Otani, Toru Fuse
• Inventors: Fuse, Toru, Otani, Sugio, Machino, Hirosi, Niijima, Kunio, Matuura, Kazusi, Yanagisawa, Sadakatsu
• Primary Examiner(s): BRITTINGHAM, DEBRA
• Application Number:
  US08/459,630
• Time in Patent Office: 928 Days
• Field of Search: 623/16, 623/18, 623/66, 424/422, 424/423, 424/424, 424/425
• US Class Current: 424/423
• CPC Class Codes: A61K 6/838 Phosphorus compounds, e.g. apatite
• CPC Class Codes: A61K 6/891 Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/02 Inorganic materials
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: C08K 3/32 Phosphorus-containing compounds
• CPC Class Codes: C08L 2666/54 Inorganic substances
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: C09D 167/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C09D167/06 takes precedence
• CPC Class Codes: C09D 7/61 inorganic

Abstract

An artificial filling and prosthetic material, characterized in that the surface of a substrate is coated with a calcium phosphate compound together with a water-insoluble and bio-degradable binder polymer. This material is capable of firmly adhering to tissue for a short time.

Claims

1. A strongly adhering artificial filling and prosthetic material, comprising:

a substrate having a porous surface selected from the group consisting of porous carbon fiber, reinforced carbon material, porous titanium and porous aluminum; and

a coating on and into said porous surface of said substrate, which coating comprises an admixture of a calcium phosphate compound and a water-insoluble and bio-degradable binder polymer in an amount of 5-30% by weight on the basis of the calcium phosphate compound, and is prepared by means of dip-coating, spray-coating or vacuum-impregnation of the porous surface using a slurry comprising said calcium phosphate compound, said water-insoluble and bio-degradable polymer and an organic solvent.

2. The artificial filling and prosthetic material of claim 1, wherein said water-insoluble and bio-degradable binder polymer contains at least one polymer selected from the group consisting of poly(3-hydroxybutyrate-4-hydroxybutyrate), poly-3-hydroxybutyrate, poly(3-hydroxybutyrate-3-hydroxyvalerate), polylactic acid, polyglycolic acid, polycaprolactone, polyethyleneadipate, polybutyleneadipate and polyhydroxyalkanoate.

3. The artificial filling and binding material of claim 1, wherein said water-insoluble and bio-degradable binder polymer contains at least one polymer selected from the group consisting of polyhydroxybutyrate and polylactic acid.

4. The artificial filling and binding material according to claim 1, wherein said calcium phosphate compound contains at least one compound selected from the group consisting of calcium secondary phosphate anhydride (CaHPO₄), calcium pyrophosphate (Ca₂ P₂ O₇), brushite (CaHPO₄.2H₂ O), tricalcium phosphate (Ca₃ (PO₄)₂) and hydroxyapatite (Ca₁₀ (PO₄)₆ (OH)₂).

5. The filling and prosthetic material according to claim 1, wherein said calcium phosphate compound contains at least one compound selected from the group consisting of tricalcium phosphate and hydroxyapatite.

6. The artificial filling and prosthetic material according to claim 1, wherein said substrate surface is porous carbon fiber reinforced carbon material.