Asymmetric membranes in delivery devices
First Claim
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1. A device for the controlled release of one or more active substances into an environment of use, said device comprising a core of said active substance or substances, with or without one or more excipients, surrounded by one or more asymmetric membranes, said assymmetric membrane comprising a thick, porous region which supports a dense, thin region.
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Abstract
A device for controlled release of an active substance through one or more asymmetric membranes by diffusion and/or osmotic pumping.
158 Citations
50 Claims
- 1. A device for the controlled release of one or more active substances into an environment of use, said device comprising a core of said active substance or substances, with or without one or more excipients, surrounded by one or more asymmetric membranes, said assymmetric membrane comprising a thick, porous region which supports a dense, thin region.
- 16. A tablet, capsule or bead for administration to an animal which releases one or more pharmaceutically active substances into said animal which comprises a core of said active substance or substances, with or without one-or more pharmaceutically acceptable excipients, said core being surrounded by one or more asymmetric membranes, said asymmetric membrane comprising a thick, porous region which supports a dense, thin region.
- 37. A method for releasing one or more active substance or substances into an environment of use which comprises placing in said environment a device containing said active substance or substances surrounded by one or more asymmetric membranes, said asymmetric membrane comprising a thick, porous region which supports a dense, thin region.
- 44. A capsule device for the controlled release of one or more active substances into an environment of use, said device comprising a core of said active substance or substances, with or without excipients, enclosed in a capsule the top or bottom of which is comprised of one or more asymmetric membranes, said asymmetric membrane comprising a thick, porous region which supports a dense, thin region.
Specification