Method of evaluating chemotherapeutic agents in vivo
First Claim
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1. A method of screening chemotherapeutic agents in vivo comprising the steps of:
- (a) implanting into a mammal at least one biocompatible, tubular, semi-permeable encapsulation device containing a group of target cells within an interior of said device wherein said device has a molecular weight cut off of greater than 50,000 daltons and said device is comprised of polyvinylidine fluoride;
(b) treating said mammal with at least one chemotherapeutic agent; and
(c) evaluating said target cells for reaction to the at least one chemotherapeutic agent.
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Abstract
The present invention relates to a method of screening chemotherapeutic agents in vivo. The method comprises implanting into a laboratory animal a biocompatible, semi-permeable encapsulation device containing a target cell-line, treating the laboratory animal with a test agent, then evaluating the target cells for reaction to the test agent.
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Citations
28 Claims
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1. A method of screening chemotherapeutic agents in vivo comprising the steps of:
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(a) implanting into a mammal at least one biocompatible, tubular, semi-permeable encapsulation device containing a group of target cells within an interior of said device wherein said device has a molecular weight cut off of greater than 50,000 daltons and said device is comprised of polyvinylidine fluoride; (b) treating said mammal with at least one chemotherapeutic agent; and (c) evaluating said target cells for reaction to the at least one chemotherapeutic agent. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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2. A method of screening chemotherapeutic agents in vivo, comprising the steps of:
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(a) implanting into a mammal at least one biocompatible, tubular, semi-permeable encapsulation device containing a group of target cells within an interior of said device, wherein said device has a molecular weight cutoff of greater than 100,000 daltons; (b) treating said mammal with at least one chemotherapeutic agent; and (c) evaluating said target cells for reaction to the at least one chemotherapeutic agent.
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3. A method of screening chemotherapeutic agents, in vivo comprising the steps of:
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(a) implanting into a mammal at least one biocompatible, tubular, semi-permeable encapsulation device, containing a group of target cells within an interior of said device, said device being comprised of polyvinylidene fluoride; (b) treating said mammal with at least one chemotherapeutic agent; and (c) evaluating said target cells for said reaction to the at least one chemotherapeutic agent.
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14. A method of screening chemotherapeutic agents in vivo comprising the steps of:
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(a) implanting into a mammal at least one biocompatible, tubular, semi-permeable encapsulation device containing a group of target cells infected with a virus; (b) treating said mammal with at least one chemotherapeutic agent; and (c) evaluating said vital infection in said target cells for effect by the at least one chemotherapeutic agent. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification