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Modular assembly of antibody genes, antibodies prepared thereby and use

DC
  • US 5,698,417 A
  • Filed: 06/06/1995
  • Issued: 12/16/1997
  • Est. Priority Date: 11/01/1985
  • Status: Expired due to Term
First Claim
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1. A process of producing an immunoglobulin fragment, said process comprising:

  • (1) culturing a bacterial host that has been transformed with a polynucleotide molecule encoding said immunoglobulin fragment under conditions that express said immunoglobulin fragment, and(2) producing and secreting said immunoglobulin fragment,wherein said polynucleotide molecule comprises;

    (1) a first DNA encoding a first secretion signal sequence operably linked to a DNA sequence encoding an immunoglobulin Fd molecule or a fragment thereof comprising a variable region, and(2) a second DNA sequence encoding a second secretion signal sequence operably linked to a DNA sequence encoding an immunoglobulin light chain or a fragment thereof comprising a variable region,wherein said immunoglobulin is capable of binding to an antigen.

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