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Thyroxin-binding HSA fragments

  • US 5,698,517 A
  • Filed: 03/21/1994
  • Issued: 12/16/1997
  • Est. Priority Date: 03/21/1994
  • Status: Expired due to Fees
First Claim
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1. A compound which is a modified form of human serum albumin (HSA) wherein said modification comprises a substitution of an amino acid of lower basicity for arginine at position 218 of said HSA, wherein said HSA(1) is a peptide fragment of HSA and is selected from a group consisting of peptides consisting of amino acid sequences found between positions 190-585, 190-487, 190-390, 190-292, 97-292 of HSA, and shorter versions of these peptides containing 1-10 fewer amino acids,(2) contains said substitution at position 218, and(3) exhibits thyroxin binding activity at least 10% of that of the corresponding full-length modified HSA,wherein said compound is purified and isolated according to standard technology.

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