Method for regulating inflammation and tumor growth with calmodulin, calmodulin analogues or calmodulin antagonists

• US 5,698,518 A
• Filed: 03/30/1994
• Issued: 12/16/1997
• Est. Priority Date: 03/30/1994
• Status: Expired due to Term

• Current Assignee: Oklahoma Medical Research Foundation
• Original Assignee: Oklahoma Medical Research Foundation
• Inventors: Houston, Donald S., Esmon, Charles T., Carson, Craig W.
• Primary Examiner(s): Tsang, Cecilia J.
• Assistant Examiner(s): Delaney, Patrick R.
• Application Number:
  US08/220,814
• Time in Patent Office: 1,357 Days
• Field of Search: 514/12, 514/21, 930/144
• US Class Current: 514/9.7
• CPC Class Codes: A61K 38/1709 from mammals
• CPC Class Codes: Y10S 930/144 Tumor necrosis factor

Abstract

A method of treating patients to inhibit inflammation is disclosed. In the method, an effective amount of calmodulin, a calmodulin analogue or calmodulin receptor agonist is administered to a patient to inhibit production of tumor necrosis factor and/or augment elastase. In another method, an effective amount of calmodulin antagonist is administered to a patient to stimulate immune response or inhibit elastase release. In another embodiment, a diagnostic test is disclosed to be used on patient blood samples to determine individual propensity to regulate tumor necrosis factor and/or elastase by calmodulin, its analogues or receptor agonists.

Claims

1. A method for treating a patient to inhibit the onset of inflammation, comprising administering to said patient an effective amount of extracellular calmodulin to inhibit production of tumor necrosis factor, whereby inflammation is inhibited.

2. A method for treating a patient for inflammation, comprising administering an effective amount of extracellular calmodulin to relieve said inflammation.

3. A method for treating a patient for conditions attributable to excess release of tumor necrosis factor, comprising administering to said patient an effective amount of extracellular calmodulin to inhibit said excess release of tumor necrosis factor.