Method for optically imaging solid tumor tissue
First Claim
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1. A method for detecting margins and dimensions of tumor tissue in an area of interest, comprising:
- (a) illuminating the area of interest with an illumination source emitting electromagnetic radiation (emr) having at least one wavelength which interacts with a dye, the emr having a wavelength of from about 450 nm to about 2500 nm;
(b) detecting one or more optical properties of the area of interest using an optical detector;
(c) acquiring and storing a control data set representing the one or more optical properties detected;
(d) administering the dye to the area of interest;
(e) detecting one or more optical properties of the area of interest subsequent to administration of the dye and acquiring a subsequent data set representing the one or more optical properties detected subsequent to administration of the dye;
(f) comparing the subsequent data set with the control data set to produce a comparison data set; and
(g) identifying changes in the one or more optical properties in the comparison data set and thereby identifying areas of solid tumor tissue, wherein the tumor tissue is characterized by one of different rates of dye uptake and different rates of dye perfusion compared to normal tissue.
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Abstract
The present invention provides a method and apparatus for determining the presence of solid tumor tissue, for identifying and mapping the margins of solid tumors during surgical or diagnostic procedures, and for grading and characterizing tumor tissue by detecting changes in the optical properties of an area of interest suspected to contain tumor tissue.
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Citations
45 Claims
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1. A method for detecting margins and dimensions of tumor tissue in an area of interest, comprising:
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(a) illuminating the area of interest with an illumination source emitting electromagnetic radiation (emr) having at least one wavelength which interacts with a dye, the emr having a wavelength of from about 450 nm to about 2500 nm; (b) detecting one or more optical properties of the area of interest using an optical detector; (c) acquiring and storing a control data set representing the one or more optical properties detected; (d) administering the dye to the area of interest; (e) detecting one or more optical properties of the area of interest subsequent to administration of the dye and acquiring a subsequent data set representing the one or more optical properties detected subsequent to administration of the dye; (f) comparing the subsequent data set with the control data set to produce a comparison data set; and (g) identifying changes in the one or more optical properties in the comparison data set and thereby identifying areas of solid tumor tissue, wherein the tumor tissue is characterized by one of different rates of dye uptake and different rates of dye perfusion compared to normal tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 34, 35, 36, 37, 38, 39)
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12. A method of grading or characterizing tumor tissue located in an area of interest, comprising:
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(a) illuminating the area of interest with an illumination source emitting electromagnetic radiation (emr) having at least one wavelength which interacts with a dye, the emr having a wavelength of from about 450 nm to about 2500 nm; (b) detecting one or more optical properties of the area of interest using an optical detector; (c) acquiring and storing a control data set representing the one or more optical properties detected; (d) administering the dye to the area of interest; (e) detecting one or more optical properties of the area of interest subsequent to administration of the dye and acquiring a subsequent data set representing the one or more optical properties detected subsequent to administration of the dye; (f) comparing the subsequent data set with the control data set to produce a comparison data set; and (g) identifying changes in the one or more optical properties in the comparison data set, wherein different degrees of malignant tumor tissue are characterized by one of different rates of dye uptake and different rates of dye perfusion compared to lower grade malignant tumor tissue and benign tumor tissue. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method for distinguishing between tumor tissue and non-tumor tissue in an area of interest, comprising:
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(a) administering a dye to the area of interest; (b) illuminating the area of interest with an illumination source emitting electromagnetic radiation (emr) having at least one wavelength which interacts with the dye, the emr having a wavelength of from about 450 nm to about 2500 nm; (c) detecting one or more optical properties of the area of interest using an optical detector; (d) acquiring and storing a data set representing the one or more optical properties detected; and (e) identifying differences in the one or more optical properties within the data set and thereby identifying areas of solid tumor tissue, wherein the solid tumor tissue is characterized by one of different rates of dye uptake and different rates of dye perfusion compared to normal tissue. - View Dependent Claims (24, 25, 26, 27, 40, 41, 42, 43, 44, 45)
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28. A method of grading or characterizing tumor tissue located in an area of interest, comprising:
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(a) administering a dye to the area of interest; (b) illuminating the area of interest with an illumination source emitting electromagnetic radiation (emr) having at least one wavelength which interacts with the dye, the emr having a wavelength of from about 450 nm to about 2500 nm; (c) detecting one or more optical properties of the area of interest using an optical detector; (d) acquiring and storing a data set representing the one or more optical properties detected; and (e) identifying differences in the one or more optical properties within the data set and thereby identifying areas of malignant and lower grade tumor tissue, wherein different degrees of malignant tumor tissue are characterized by one of different rates of dye uptake and different rates of dye perfusion compared to the lower grade malignant tumor tissue and benign tumor tissue. - View Dependent Claims (29, 30, 31, 32)
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33. A method for detecting margins and dimensions of tumor tissue in an area of interest, comprising:
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(a) illuminating the area of interest with an illumination source emitting electromagnetic radiation (emr) having at least a first and a second, different, wavelength which interact with a dye, the emr being in the visible or infrared regions; (b) detecting one or more optical properties of the area of interest for each of the first and second wavelengths of emr using an optical detector; (c) acquiring and storing a first and a second control data set representing the one or more optical properties detected; (d) administering the dye to the area of interest; (e) detecting one or more optical properties of the area of interest for each of the first and second wavelengths of emr subsequent to administration of the dye and acquiring a first and a second subsequent data set representing the one or more optical properties detected subsequent to administration of the dye; (f) comparing the first subsequent data set with the first control data set and the second subsequent data set with the second control data set to produce a first and a second comparison data set; (g) obtaining an enhanced comparison data set by rationing the first comparison data set to the second comparison data set; and (h) identifying changes in the one or more optical properties in the enhanced comparison data set and thereby identifying areas of solid tumor tissue, wherein the solid minor tissue is characterized by one of different rates of dye uptake and different rates of dye perfusion compared to normal tissue.
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Specification