Extracts of ginkgo biloba and their methods of preparation
First Claim
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1. A composition comprising compounds extracted from leaves of Ginkgo biloba and wherein inactive lipophilic substances which can be extracted by n-hexane, n-heptane or a solvent comprising toluene and n-butanol wherein the volume ratio of toluene:
- butanol is from 6;
1 to 12;
1 are absent, said composition including the following components;
space="preserve" listing-type="tabular">______________________________________ ginkgo flavone glucosides 24 wt % proanthocyanidines 9 wt % ginkgolides 3.6 wt % bilobalide 3.1 wt % sulphuric ash 0.1 wt %. ______________________________________
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Abstract
A process is provided for producing a purified extract from Ginkgo biloba leaves by solvent extraction with selected solvents. In the process, a crude or partially purified extract is subjected to solvent extraction with a solvent comprising toluene and n-butanol. Pharmaceutical compositions comprising dimeric flavones and/or polyphenols are also described.
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2 Claims
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1. A composition comprising compounds extracted from leaves of Ginkgo biloba and wherein inactive lipophilic substances which can be extracted by n-hexane, n-heptane or a solvent comprising toluene and n-butanol wherein the volume ratio of toluene:
- butanol is from 6;
1 to 12;
1 are absent, said composition including the following components;
space="preserve" listing-type="tabular">______________________________________ ginkgo flavone glucosides 24 wt % proanthocyanidines 9 wt % ginkgolides 3.6 wt % bilobalide 3.1 wt % sulphuric ash 0.1 wt %. ______________________________________ - View Dependent Claims (2)
- butanol is from 6;
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Current AssigneeIndena S.P.A.
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Original AssigneeIndena S.P.A.
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InventorsBombardelli, Ezio, Bertani, Marco, Mustich, Giuseppe
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Primary Examiner(s)Tsang, Cecilia J.
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Assistant Examiner(s)TOUZEAU, LYNN
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Application NumberUS08/615,536Time in Patent Office651 DaysField of Search424/195.1, 514/12US Class Current424/752CPC Class CodesA61K 2300/00 Mixtures or combinations of...A61K 31/35 having six-membered rings w...A61K 31/365 LactonesA61K 31/70 Carbohydrates; Sugars; Deri...A61K 36/16 Ginkgophyta, e.g. Ginkgoace...
