Transdermal therapeutic system comprising galanthamine as active component

• US 5,700,480 A
• Filed: 09/29/1995
• Issued: 12/23/1997
• Est. Priority Date: 01/23/1993
• Status: Expired due to Term

• Current Assignee: LTS Lohmann Therapie-Systeme AG
• Original Assignee: LTS Lohmann Therapie-Systeme AG
• Inventors: Deurer, Lothar, Hille, Thomas
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Shelborne, Kathryne E.
• Application Number:
  US08/495,609
• Time in Patent Office: 816 Days
• Field of Search: 424/448, 424/449, 424/487
• US Class Current: 424/448
• CPC Class Codes: A61K 31/55 having seven-membered rings, e.g. azelastine, pentylenetetrazole
• CPC Class Codes: A61K 9/7061 Polyacrylates
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 27/12 for cataracts
• CPC Class Codes: A61P 37/02 Immunomodulators

Abstract

A transdermal therapeutic system (TTS) for the administration of galanthamine to the skin each system having a backing layer which is impermeable to active substances and a pressure sensitive adhesive reservoir layer, wherein the reservoir layer comprises 40-80% wt. polymeric material selected from the group consisting of polyacrylates, 0.1-30%-wt. plasticizers, and 0.1-30%-wt. galanthamine base or one of its pharmaceutically acceptable salts.

Claims

1. A transdermal therapeutic system (TTS) for the administration of galanthamine to the skin said system having a backing layer which is impermeable to active substances and a pressure sensitive adhesive reservoir layer, characterized in that the reservoir layer comprises 40-80%-wt. polymer material selected from the group consisting of polyacrylates, 0.1-30% wt. plasticizers, and 0.1-30%-wt. galanthamine base or one of the pharmaceutically acceptable salts thereof.

2. The TTS according to claim 1 characterized in that the pressure sensitive adhesive layer comprises 0.1-30%-wt. penetration enhancers.

3. The TTS according to claim 2 characterized in that the penetration enhancer is a carboxylic acid.

4. The TTS according to claim 1 characterized in that the polymer material selected from the group consisting of polyacrylates is a polymerization product of acrylic acid and the esters thereof or of methacrylic acid and the esters thereof.

5. The TTS according to claim 4 characterized in that the esters of acrylic acid comprise as alcohol components straight-chain or branched alcohols having 4-10 carbons.

6. The TTS according to claim 4 characterized in that the esters of acrylic acid comprise as alcohol components alcohols having 2-4 carbons.

7. The TTS according to claim 4 characterized in that the esters of methacrylic acid comprise amino alcohols as alcohol components.

8. The TTS according to claim 4 characterized in that the polymer material comprises self-crosslinking or non-self-crosslinking acrylate copolymers.

9. The TTS according to claim 1 characterized in that the system is provided with a removable protective layer.