Transdermal drug delivery process
First Claim
1. A transdermal drug delivery process by iontophoresis for a calcitonin, its derivative having similar function or activity to the calcitonin or a salt thereof, which comprises the step of applying a substantially constant voltage within the range of 3 to 20 V at a current density of 0.05 to 0.5 mA/cm2, wherein the process comprises:
- (1) at least one cycle comprising;
(1a) a precedent voltage application step of applying a substantially constant voltage for 1 to 30 minutes, and(1b) a succeeding voltage application step of applying a substantially constant voltage, which voltage is lower than the applied voltage of the precedent voltage application step (1a), for 15 to 100 minutes, or(2) at least one cycle comprising;
(2a) a voltage application step of applying a substantially constant voltage in the range of 4 to 15 V for 1 to 30 minutes.(2b) a step of interrupting the voltage application for 1 to 30 minutes, and(2c) a voltage application step of applying a substantially constant voltage, which voltage is substantially the same as the applied voltage of the voltage application step (2a) and in the range of 4 to 15 V, for 1 to 30 minutes.where the current density in the voltage application steps (2a) and (2c) is maintained at 0.08 to 0.3 mA/cm2.
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Accused Products
Abstract
A calcitonin, its derivative or a salt thereof is transdermally delivered by iontophoresis in which a substantially constant voltage in the range of 3 to 20 V is applied at an electric current of 0.05 to 0.5 mA/cm2. In this process, the calcitonin can be delivered transdermally with a higher absorptivity by applying a higher voltage for a short period (at a voltage of about 6 to 14 V for about 5 to 15 minutes) in the initial stage of the voltage application, and then applying a lower voltage for a long period (at a voltage of about 3 to 9 V for about 30 to 40 minutes).
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Citations
26 Claims
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1. A transdermal drug delivery process by iontophoresis for a calcitonin, its derivative having similar function or activity to the calcitonin or a salt thereof, which comprises the step of applying a substantially constant voltage within the range of 3 to 20 V at a current density of 0.05 to 0.5 mA/cm2, wherein the process comprises:
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(1) at least one cycle comprising; (1a) a precedent voltage application step of applying a substantially constant voltage for 1 to 30 minutes, and (1b) a succeeding voltage application step of applying a substantially constant voltage, which voltage is lower than the applied voltage of the precedent voltage application step (1a), for 15 to 100 minutes, or (2) at least one cycle comprising; (2a) a voltage application step of applying a substantially constant voltage in the range of 4 to 15 V for 1 to 30 minutes. (2b) a step of interrupting the voltage application for 1 to 30 minutes, and (2c) a voltage application step of applying a substantially constant voltage, which voltage is substantially the same as the applied voltage of the voltage application step (2a) and in the range of 4 to 15 V, for 1 to 30 minutes. where the current density in the voltage application steps (2a) and (2c) is maintained at 0.08 to 0.3 mA/cm2. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 22, 23, 24)
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20. An apparatus for iontophoresis which is provided with:
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(i) an applicator comprising (ia) an electrode applicable with a direct-current voltage and (ib) an interface conductible to the electrode, capable of contacting a skin, possessing a calcitonin, its derivative having similar function or activity to the calcitonin or a salt thereof, transmittablly and capable of being supplied with a liquid for dissolving the calcitonin, its derivative or a salt thereof, (ii) an electric power supply for applying a direct-current voltage to the electrode, and (iii) a voltage stabilizing means for applying a substantially constant direct-current voltage in the range of 3 to 20 V supplied from the electric power supply to the electrode with maintaining a current density of 0.05 to 0.5 mA/cm2. - View Dependent Claims (25, 26)
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21. A method of applying a voltage for enhancing transdermal absorption of a calcitonin with the use of an applicator comprising an electrode applicable with a direct-current voltage, and an interface conductible with the electrode, capable of contacting a skin, possessing a calcitonin, its derivative having similar function or activity to the calcitonin or a salt thereof transmittablly and capable of being supplied with a liquid for dissolving the calcitonin, its derivative or a salt thereof, wherein a substantially constant direct-current voltage in the range of 3 to 20 V is applied to the electrode with maintaining a current density at 0.05 to 0.5 mA/cm2, and wherein said process comprises:
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(1) at least one cycle comprising; (1a) a precedent voltage application step of applying a substantially constant voltage for 1 to 30 minutes, and (1b) a succeeding voltage application step of applying a substantially constant voltage, which voltage is lower than the applied voltage of the precedent voltage application step (1a), for 15 to 100 minutes, or (2) at least one cycle comprising; (2a) a voltage application step of applying a substantially constant voltage in the range of 4 to 15 V for 1 to 30 minutes, (2b) a step of interrupting the voltage application for 1 to 30 minutes, and (2c) a voltage application step of applying a substantially constant voltage, which voltage is substantially the same as the applied voltage of the voltage application step (2a) and in the range of 4 to 15 V, for 1 to 30 minutes, where the current density in the voltage application steps (2a) and (2c) is maintained at 0.08 to 0.3 mA/cm2.
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Specification