Method and system for Doppler ultrasound measurement of blood flow

• US 5,701,898 A
• Filed: 05/21/1996
• Issued: 12/30/1997
• Est. Priority Date: 09/02/1994
• Status: Expired due to Term

• Current Assignee: The United States of America As Represented By The Secretary of Agriculture
• Original Assignee: United States Department Of Health And Human Services (Government of the United States of America)
• Inventors: Jones, Michael, Tucker, Eben E., Vivino, Mark A., Adam, Dan R., Kempner, Kenneth M.
• Primary Examiner(s): JAWORSKI, FRANCIS J
• Application Number:
  US08/651,022
• Time in Patent Office: 588 Days
• Field of Search: 128/660.04, 128/660.05, 128/660.07-660.1, 364/413.25
• US Class Current: 600/454
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/4254 using sensors mounted on the probe
• CPC Class Codes: A61B 8/483 involving the acquisition of a 3D volume of data
• CPC Class Codes: A61B 8/543 involving acquisition triggered by a physiological signal
• CPC Class Codes: G01S 15/8979 Combined Doppler and pulse-echo imaging systems
• CPC Class Codes: G01S 15/8984 Measuring the velocity vector
• CPC Class Codes: G01S 15/899 Combination of imaging systems with ancillary equipment
• CPC Class Codes: G01S 15/8993 Three dimensional imaging systems
• CPC Class Codes: G01S 7/5205 Means for monitoring or calibrating

Abstract

A method and system for providing Doppler data that is corrected for misalignment between the flow direction within a vessel and the beam orientation of the ultrasound probe. A conventional ultrasonic Doppler color mapping system is adapted to include a system to measure and record the free space position and orientation of the ultrasonic probe, as well as a system to generate and record the experiment time. A set of 2D image planes is acquired, each plane labelled with time, position, and orientation data. A structural representation according to the acquired data is used to determine the flow direction for the imaged vessel structure. Based on this identified flow direction, and the orientation and position information for each acquired 2D slice, the 2D Doppler signals are appropriately transformed into corrected velocity values. These corrected velocity values may then be used to construct a 3D flow field as a function of time.

Claims

1. A Doppler ultrasound apparatus for measuring flow in a localized region within a vessel, said flow having an associated velocity, said apparatus comprising:

an ultrasound probe for generating and detecting an incident and reflected ultrasound signal, respectively, said incident and reflected ultrasound signal including a Doppler ultrasound signal;

a position and orientation system which generates an orientation and position signal for said ultrasound probe; and

a processor which provides a corrected ultrasound signal representing said flow, based on said orientation and position signal, and on said ultrasound signal to generate a three-dimensional representation of said vessel for determining a three-dimensional flow direction for said localized region within the vessel;

wherein said corrected ultrasound signal compensates for errors in measuring said flow that are due to angular misalignment of said ultrasound probe relative to said velocity of said flow in said localized region.

2. The apparatus according to claim 1, wherein said ultrasound signal includes Doppler information for a plurality of localized regions within a two dimensional region scanned by said ultrasound probe according to a plurality of scanning lines.

3. The apparatus according to claim 2, wherein said ultrasound probe scans a plurality of two dimensional regions.

4. The apparatus according to claim 3, wherein said plurality of two dimensional regions are scanned as a function of time, and said apparatus provides a time dependent three dimensional flow image.

5. The apparatus according to claim 1, wherein said ultrasound signal includes a structural ultrasound signal.

6. The apparatus according to claim 1, wherein said ultrasound signal includes a time series of structural information and Doppler information.

7. The apparatus according to claim 6, further comprising a means for acquiring said ultrasound signal in a known time relationship with the cardiac cycle of a body observed by the Doppler ultrasound apparatus.

8. The apparatus according to claim 7, wherein said ultrasound signal is acquired over a plurality of cardiac cycles, said processor separately processing data sets of said time series of structural information and Doppler information according to the acquisition time for each data set relative to the cardiac cycle.

9. The apparatus according to claim 7, wherein said corrected ultrasound signal represents a corrected flow velocity.

10. The apparatus according to claim 1, wherein said position and orientation system includes a transmitter and a receiver, one of said transmitter and receiver fixed in space relative to other of said transmitter and receiver, one of said transmitter and receiver fixably mounted to said ultrasound probe, said position and orientation system including a processor for generating an orientation matrix which relates the spatial transformation between the respective coordinate systems of the transmitter and the receiver, thereby providing said orientation and position signal.

11. The apparatus according to claim 1, wherein said processor provides said corrected ultrasound signal based on determining a smooth and continuously changeable central axis for flow according to structural information in said Doppler ultrasound signal.

20. The apparatus according to claim 1, wherein said ultrasound signal includes a structural ultrasound signal in addition to the Doppler ultrasound signal, and wherein said processor provides said corrected ultrasound signal based on determining a smooth and continuously changeable central axis for flow according to the structural ultrasound signal.

12. A Doppler ultrasound apparatus for measuring flow velocity in a localized region within a vessel using Doppler ultrasound, said apparatus comprising:

an ultrasound probe for generating and detecting an incident and reflected ultrasound signal, respectively, said incident and reflected ultrasound signal including a Doppler ultrasound signal;

means for generating an orientation and position signal for said ultrasound probe; and

means for processing said orientation and position signal, and said ultrasound signal into a corrected ultrasound signal representing said flow velocity based on generating a three-dimensional representation of said vessel for determining a three-dimensional flow direction for said localized region within the vessel;

wherein said corrected ultrasound signal compensates for errors in measuring said flow that are due to angular misalignment of said ultrasound probe relative to said flow velocity in said localized region.

13. The apparatus according to claim 12, further comprising means for generating a time code associated with the time of detecting said ultrasound signal, and wherein said ultrasound signal includes a time series of image data corresponding to a two dimensional region scanned by said ultrasound probe according to a plurality of scan lines.

14. The apparatus according to claim 13, wherein said ultrasound signal includes a image data for a plurality of two dimensional regions, and further comprising means for generating a three dimensional time dependent representation of said flow according to said corrected ultrasound signal.

15. A method for measuring a flow in a localized region within a vessel using a Doppler ultrasound apparatus, said flow having an associated velocity, said method comprising the steps of:

generating and detecting an incident and reflected ultrasound signal, respectively, using an ultrasound probe, said incident and reflected ultrasound signal including a Doppler ultrasound signal;

generating an orientation and position signal for said ultrasound probe; and

processing said orientation and position signal, and said ultrasound signal into a corrected ultrasound signal representing said flow by generating a three-dimensional representation of said vessel for determining a three-dimensional flow direction for said localized region within the vessel;

wherein said corrected ultrasound signal compensates for errors in measuring said flow that are due to angular misalignment of said ultrasound probe relative to said velocity of said flow in said localized region.

16. The method according to claim 15, wherein said processing step includes determining a smooth and continuously changeable central axis for flow according to structural information in said Doppler ultrasound signal.

17. The method according to claim 15, further comprising the step of generating a three dimensional flow image according to said corrected ultrasound signal.

18. The method according to claim 17, wherein said three dimensional flow image corresponds to flow at a particular time with respect to the cardiac cycle of a body observed by the Doppler ultrasound apparatus.

19. The method according to claim 17, further comprising the step of generating said three dimensional flow image as a function of time.