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Perfluorobutane ultrasound contrast agent and methods for its manufacture and use

  • US 5,701,899 A
  • Filed: 05/31/1995
  • Issued: 12/30/1997
  • Est. Priority Date: 05/12/1993
  • Status: Expired due to Term
First Claim
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1. A pharmaceutically acceptable ultrasound contrast agent which relies on microbubbles for echogenicity, said agent comprising:

  • microbubbles formed from a solution of a filmogenic protein and a saccharide wherein said saccharide comprises less than about 40% by weight of said solution wherein said microbubbles have an internal atmosphere enhanced with perfluorobutane gas.

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