Fluid distribution system

• US 5,701,937 A
• Filed: 09/19/1995
• Issued: 12/30/1997
• Est. Priority Date: 11/09/1992
• Status: Expired due to Fees

• Current Assignee: Pharmacia & Upjohn AB (Pharmacia Corp.)
• Original Assignee: Pharmacia & Upjohn AB (Pharmacia Corp.)
• Inventors: Bourboulou, Yves, Tronchet, Jean, Philippon, Celine, Boucheteil, Micheline
• Primary Examiner(s): JACYNA, J CASIMER
• Application Number:
  US08/432,127
• Time in Patent Office: 833 Days
• Field of Search: 141/2, 141/9, 141/10, 141/18, 141/21, 141/114, 141/100, 141/102, 141/104, 141/234, 141/236, 141/237, 141/240, 141/242-244, 141/246, 141/313, 141/314, 141/317, 141/324-326, 604/408, 604/410
• US Class Current: 141/244
• CPC Class Codes: A61J 1/10 Bag-type containers
• CPC Class Codes: A61J 3/002 Compounding apparatus specially for enteral or parenteral nutritive solutions bottling liquids B67C

Abstract

Provided is a closed fluid distribution system with manifold devices for aseptically distributing fluids in conduits from a controlled atmosphere zone for production of the fluids to collapsible storage containers located outside the zone. The manifold device facilitates filling of a plurality of containers with one or several compartments. The invention is especially advantageous when regarding that the system can be used for aseptically filling both one-, two- or three-compartment containers for storage, with possibilities of switching between the types of containers.

Claims

1. A closed aseptic system for aseptically distributing a plurality of fluids from conduits leading from a controlled atmosphere zone for production of the fluids to containers having several compartments by several manifold devices located outside the said zone characterized in that each manifold device (3, 3'"'"') has a singular fluid inlet (4, 4'"'"') sealingly connected with a determined conduit (1) for the distribution of one determined fluid, wherein each manifold device is provided with a plurality of fluid outlet orifices (5, 5'"'"') sealingly connected to the containers (8) by tubings (6) and wherein,

a) the cross-sectional area of said manifold device inlet is selected from the group consisting of being larger than the sum of the cross-sectional areas of said outlet orifices, and

b) the relationship of the diameter of the manifold device inlet and a manifold outlet orifices is about 3:

2, in order to obtain that

(i) the fluid flow is substantially the same in each tubing (6) that connects the outlet orifices of the manifolding device to the containers; and

that

(ii) the pressure drop is substantially the same in all outlet orifices of the manifold device; and

wherein said system is adapted for filling several compartments of the containers simultaneously with different fluids wherein each manifold device is selected from the group consisting of being assembled by attachment means and pre-manufactured in an assembly, so that each fluid will be distributed in its predetermined manifold device to its designated compartment of multi-compartment containers and wherein said multi-compartment containers are collapsible.

2. A system according to claim 1 characterized in that each manifold device is assembled in a housing (7) which includes means for providing closed communication between the outlet orifices of each manifold device and the tubings connected to multi-compartment containers.

3. A system according to claim 2 characterized in that each conduit leading from the controlled atmosphere zone to the manifold device is provided with a sterile filter (2).

4. A system according to claim 3 characterized in that the fluids are parenterally administerable medical, nutritional fluids or both distributed from a controlled atmosphere zone for sterile production of the said fluids.

5. A system according to claim 2 characterized in that the fluids are parenterally administerable fluids selected from the group consisting of medical fluids, nutritional fluids and mixtures thereof distributed from a controlled atmosphere zone for sterile production of the said fluids.

6. A system according to claim 1 characterized in that each conduit leading from the controlled atmosphere zone to the manifold device is provided with a sterile filter (2).

7. A system according to claim 1 characterized in that each conduit leading from the controlled atmosphere zone to the manifold device is provided with a sterile filter (2).

8. A system according to claim 7 characterized in that the fluids are parenterally administerable fluids selected from the group consisting of medical fluids, nutritional fluids and mixtures thereof, distributed from a controlled atmosphere zone for sterile production of the said fluids.

9. A system according to claim 1 characterized in that the fluids are parenterally administerable fluids selected from the group consisting of medical fluids, nutritional fluids and mixtures thereof distributed from a controlled atmosphere zone for sterile production of the said fluids.