Implantable artificial endocrine pancreas

• US 5,702,444 A
• Filed: 09/11/1995
• Issued: 12/30/1997
• Est. Priority Date: 09/11/1995
• Status: Expired due to Fees

• Current Assignee: STRUTHERS, MEHTA AND MAXWELL
• Original Assignee: STRUTHERS, MEHTA AND MAXWELL
• Inventors: Struthers, Ralph C., Mehta, Devendra V.
• Primary Examiner(s): Milano, Michael J.
• Application Number:
  US08/526,075
• Time in Patent Office: 841 Days
• Field of Search: 623/11, 435/178, 435/268, 210/265, 210/645
• US Class Current: 623/23.64
• CPC Class Codes: A61K 2035/126 Immunoprotecting barriers, e.g. jackets, diffusion chambers
• CPC Class Codes: C12N 5/0677 Three-dimensional culture, tissue culture or organ culture; Encapsulated cells

Abstract

An implantable artificial endocrine pancreas comprising a reactive body of soft, plastic, biocompatible, porous hydratable material supporting a multiplicity of endocrine pancreatic islets in isolated spaced relationship from each other; and, a microporous barrier membrane enveloping and supporting the body, in spaced relationship from the pancreatic islets therein and through which molecules having a molecular weight greater than 60,000 Daltons cannot move.

Claims

1. An implantable artificial endocrine pancreas device including a multiplicity of endocrine islets, a jacket of biocompatible, soft, plastic, hydratable porous material about each islet, the jackets about adjacent islets are in bridging contact with each other and support the islets in predetermined spaced relationship with each other, a matrix body of biocompatible, plastic, porous, hydratable material is formed about and between the jacketed islets and supports the jacketed islets in fixed position, a biocompatible barrier membrane structure is positioned in supporting engagement with exterior surfaces of the matrix and includes microporous material that excludes free diffusion and movement of materials the molecular size of which, is greater than 60,000 Daltons.

2. The device set forth in claim 1 wherein the material of which the jackets are made is a hydrogel free of cross-links.

3. The device set forth in claim 1 wherein the material of which the matrix is made is a cross-link hydrogel.

4. The device set forth in claim 1 wherein the materials of which the jackets and matrix are made are hydrogels.

5. The device set forth in claim 4 wherein the hydrogel of which the jackets are made is free of cross-links.

6. The device set forth in claim 4 wherein the hydrogel of which the jackets are made is free of cross-links;

and, the material of which the matrix is made is cross-linked.

7. The device set forth in claim 1 wherein the barrier membrane structure is a laminated structure including a carrier layer of substantially dimensionally stable, flexible and porous material with an inside surface opposing the matrix and an oppositely disposed outer surface;

and, a layer of microporous material overlying the outer surface of the carrier layer.

8. A biocompatible artificial pancreas device including an exterior barrier membrane structure that excludes free diffusion and movement of material therethrough the molecular size of which is greater than 60,000 Daltons;

a matrix of porous plastic hydratable material contained within the barrier membrane structure;

a multiplicity of endocrine islets within and carried by the matrix in predetermined minimum spaced relationship one from the other; and

, wherein the endocrine islets are encapsulated within jackets of biocompatible, plastic porous material, the wall thickness of the jacket about each islet is equal to at least one-half the predetermined minimum space between adjacent islets.

9. The device set forth in claim 8 wherein jackets about adjacent islets are in contact with each other and supported against deformation and in set position by the matrix.

10. The device set forth in claim 9 wherein the material of which the jackets are made is a non-linked dehydratable and rehydratable hydrogels and the material of which the matrix is made is a cross-linked dehydratable and rehydratable hydrogel.