Multiple channel biomedical digital telemetry transmitter

• US 5,704,351 A
• Filed: 02/28/1995
• Issued: 01/06/1998
• Est. Priority Date: 02/28/1995
• Status: Expired due to Term

• Current Assignee: Mortara Instrument, Inc. (Baxter International Inc.)
• Original Assignee: Mortara Instrument, Inc. (Baxter International Inc.)
• Inventors: Mortara, David W., Sueppel, Brian E.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US08/396,151
• Time in Patent Office: 1,043 Days
• Field of Search: 128/903, 128/630, 128/696
• US Class Current: 600/382
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/276 Protection against electrode failure
• CPC Class Codes: A61B 5/29 for permanent or long-term implantation
• CPC Class Codes: A61B 5/7232 involving compression of the physiological signal, e.g. to extend the signal recording period
• CPC Class Codes: A61N 1/3727 characterised by the modulation technique
• CPC Class Codes: Y10S 128/904 Telephone telemetry

Abstract

A digital telemetry transmitter for transmitting eight channels of diagnostic quality electrocardiographic data has input circuitry for receiving analog EKG signals originating at electrodes on the patient. The input circuitry includes a circuit for ascertaining the impedance of the electrode connection to the patient and to indicate an electrode fault. EKG signals from the input circuit are provided to a digital/analog converter for converting the analog signals into corresponding digital signals. The analog/digital converter may comprise an eight channel, 20-bit converter, sampling the input signals at a frequency of 10 KHz and providing a digital output signal having a frequency of 500 Hz. The output of the analog/digital converter is provided to a microprocessor control which provides a digital EKG modulating output signal. The output signal is periodically inverted to avoid stationarity in the transmitted data. The output signal includes error correction data that enables a receiver for the transmitted data to correct the digital EKG signal for noise. The microprocessor control changes the resolution of the transmitter when large signal changes occur in the data to accommodate such signals and to provide data compression. An rf signal generator generates an rf carrier signal. The modulating output signal of the microprocessor control is provided as a frequency modulating signal to the rf signal generator. The rf signal generator is stabilized against alterations due to reflected antenna loading.

Claims

1. A biomedical telemetry transmitter suitable for transmitting data from a plurality of biomedical data signals originating as analog input signals produced by biomedical sensors, said telemetry transmitter comprising:

an input circuit for receiving the analog input signals and providing the biomedical data signals;

an analog/digital converter for converting the biomedical data signals to corresponding digital signals;

control means coupled to said analog/digital converter for receiving said digital signals, said control means including means for providing a serial digital modulating signal from the digital signals of said analog/digital converter and for introducing data compression in the provision of said digital modulating signal;

an rf signal generating means for generating an rf carrier signal; and

means coupled to said control means and to said rf signal generating means for frequency modulating the rf carrier signal with said digital modulating signal to form a transmission signal for said transmitter containing data from said plurality of biomedical data signals.

2. A biomedical telemetry transmitter according to claim 1 wherein said control means is further defined as including means establishing a resolution for the digital modulating signal and wherein said control means includes means for altering the resolution of the digital modulating signal, thereby to achieve data compression.

3. A biomedical telemetry transmitter according to claim 2 wherein said analog/digital converter includes means for sampling the analog input signals at sampling intervals, wherein said control means includes means for determining the maximum signal change in the biomedical data signals between two successive signal samples, wherein said control means further includes means for providing error correction data in the digital modulating signal indicative of the maximum signal change occurring in any of the biomedical data signals for use in limiting the data change in any of the biomedical data signals to said maximum signal change, the error correction data having a maximum value, and wherein said altering means is further defined as altering the resolution of the digital modulating signal when the error correction data is in a maximum value condition.

4. A biomedical telemetry transmitter according to claim 2 wherein said control means receives digital signals from said analog/digital converter in the form of digital words having a given number of bits expressing the magnitude of the analog input signals, wherein said control means provides a digital modulating signal in which the magnitude of the biomedical data is expressed in digital words having a fewer number of bits and selected from said given number of bits, and wherein said altering means of said control means shifts the bits selected from the given number of bits that are used to form the digital words in the digital modulating signal to alter the resolution of the digital modulating signal.

5. A biomedical telemetry transmitter according to claim 4 wherein the biomedical data signals change in magnitude, and wherein said altering means alters the resolution of the digital modulating signal responsive to magnitudinal changes in a biomedical data signal.

6. A biomedical telemetry transmitter according to claim 4 wherein said control means comprises means selecting from said given number of bits, a fewer number of bits for forming digital words that are outputted by said control means;

and said altering means comprises means for shifting the bits selected from the given number of bits used to form the digital words in the digital modulating signal in the direction of the most significant bit, thereby to alter the resolution of the digital modulating signal while achieving a data compression related to the number of bits by which the digital word of the signal is shifted.

7. A biomedical telemetry transmitter according to claim 6 wherein the magnitude of said digital modulating signal changes and wherein said altering means carries out bit shifting and alters the resolution of said digital modulating signal in response to digital modulating signal magnitude changes.

8. A biomedical telemetry transmitter according to claim 4 wherein said analog/digital converter includes means for sampling the analog input signals at sampling intervals, wherein said control means includes means for determining the maximum signal change in the biomedical data signals between two successive signal samples, wherein said control means further includes means for providing error correction data in the digital modulating signal indicative of the maximum signal change occurring in any of the biomedical data signals for use in limiting the data change in any of the biomedical data signals to said maximum signal change, the error correction data having a maximum value, and wherein said altering means is further defined as altering the resolution of the digital modulating signal when the error correction data is in a maximum value condition.

9. A biomedical telemetry transmitter according to claim 1 wherein said control means further includes means for forming a plurality of data frames, each of said data frames containing data from each of said plurality of biomedical data signals, and wherein said control means further includes means for repetitiously incorporating the data frames in the serial digital modulating signal.

10. A biomedical telemetry transmitter according to claim 1 wherein said analog/digital converter includes means for sampling the analog input signals at sampling intervals, wherein said control means includes means for determining the maximum signal change in the biomedical data signals between two successive signal samples, and wherein said control means further includes means for providing error correction data in the digital modulating signal indicative of the maximum signal change occurring in any of the biomedical data signals for use in limiting the data change in any of the biomedical data signals to said maximum signal change.

11. A biomedical telemetry transmitter according to claim 10 wherein said control means further includes means for forming a plurality of data frames, each of the data frames containing data from each of the plurality of biomedical data signals, wherein said control means further includes means for repetitiously incorporating data frames in the serial digital modulating signal, and wherein said means for providing error correction data incorporates error correction data in each of the data frames for use in limiting the data change in any of the biomedical data signals of the frame to said maximum change.

12. A biomedical telemetry transmitter according to claim 10 wherein the error correction data has a maximum value and wherein said control means is further defined as changing the resolution of the digital modulating signal when the error correction data is in a maximum value condition.

13. A biomedical telemetry transmitter according to claim 10 wherein a plurality of digital signals corresponding to biomedical data signals are successively provided to a receiver and wherein said control means provides error correction data in the form of a means by which the effects of spurious signals may be minimized in the plurality of digital signals transmitted to the receiver, the digital signals corresponding to the biomedical data signals and provided by said analog/digital converter having origins in a common signal source, said control means comprising:

means for determining the amount of change occurring between two successive digital signal samples of any one of said digital signals of the analog/digital converter; and

means for associating with at least one of said digital signals, an indicator indicative of the amount of said change, said indicator comprising said spurious signal minimizing means and being usable by the receiver to limit the change in successively transmitted pluralities of said digital signals to that represented by said indicator.

14. A biomedical telemetry transmitter according to claim 13 wherein the resolution of the digital signals is changeable, wherein there is a limit to the amount of digital signal change that can be indicated by said indicator, wherein said control means is further defined as including means establishing a resolution for the digital modulating signal, wherein said control means includes means for altering the resolution of the digital modulating signal to achieve data compression and wherein when said indicator provides an indication indicative of the change limit condition, said altering means alters the resolution of the digital signal.

15. A biomedical telemetry transmitter according to claim 13 wherein said control means is further defined as forming said digital signals into a plurality of data frames, each of which contain data of said plurality of digital signals, and wherein said associating means incorporates an indicator in each of said data frames or use in limiting the data change of the received data in any of said digital signals of said frame.

16. A biomedical telemetry transmitter according to claim 13 wherein said biomedical telemetry transmitter is further defined as a biomedical telemetry transmitter for minimizing the effects of spurious signals in telemetrically transmitted digital EKG data signals.

17. A biomedical telemetry transmitter according to claim 1 wherein the digital modulating signal is formed of bits and wherein said control means is further defined as periodically inverting the bits of the digital modulating signal to avoid stationarity in the data of the digital modulating signal.

18. A biomedical telemetry transmitter according to claim 17 wherein the digital modulating signal is formed of a succession of digital bits capable of having one signal state or another signal state, said digital modulating signal being subject to a condition of stationarity in which the bits are of one signal state or the another signal state in a given period of time;

said control means includes means for avoiding the condition of stationarity comprising;

means for dividing the digital modulating signal into sequential increments comprising at least one bit; and

means for inverting the bits of selected ones of the increments of the digital modulating signal to avoid the condition of stationarity.

19. A biomedical telemetry transmitter according to claim 18 wherein said means for dividing the data signal into sequential increments is further defined as dividing the data signal into sequential increments comprising a plurality of data bits.

20. A biomedical telemetry transmitter according to claim 19 wherein said inverting means is further defined as inverting the bits of every other one of said sequential increments.

21. A biomedical telemetry transmitter according to claim 19 wherein said inverting means is further defined as carrying out the inversion of selected ones of the increments so as to create a desired frequency characteristic in the digital modulating signal.

22. A biomedical telemetry transmitter according to claim 1 wherein said transmitter has a transmitting antenna coupled to said rf signal generating means and wherein said transmitter is subject to instabilities as a result of changes in loading reflected from the antenna, wherein said rf signal generating means includes means for stabilizing said transmitter against such instabilities comprising:

regulator means for establishing the frequency of the rf carrier signal;

means for providing a predetermined regulating response time for said regulator means sufficient to maintain the established frequency of the rf carrier signal in the face of changes in reflected loading from the antenna, the response time providing a corresponding bandwidth to said rf signal generating means, the bandwidth being defined by a lower cutoff frequency and an upper cutoff frequency;

wherein the digital modulating signal possesses frequency properties which lie in a frequency range having frequencies less than, and frequencies greater than, said bandwidth upper cutoff frequency, so that a portion of the frequency range lies within the bandwidth of the rf signal generating means; and

wherein said rf signal generating means includes a preemphasis circuit for increasing the magnitude of the portion of digital modulating signal having frequencies less than the upper cutoff frequency of the bandwidth of the rf signal generating means.

23. A biomedical telemetry transmitter according to claim 1 wherein the biomedical sensors comprise electrodes connected to a patient and wherein said input circuit has means couplable to the electrodes for ascertaining the impedance of the connections of the electrodes to the patient.

24. A biomedical telemetry transmitter according to claim 23 wherein the connection of the electrodes to the patient gives rise to an electrical impedance and said telemetry transmitter includes a visual display unit coupled to said ascertaining means in said input circuit for providing a visual indication of the magnitude of the impedance of the connections of the electrodes to the patient.

25. A biomedical telemetry transmitter according to claim 1 wherein the plurality of biomedical data signals originate at a plurality of biomedical sensors connected to a patient and wherein said input circuit has means couplable to the biomedical sensors for ascertaining the loss of a sensor connection to the patient.

26. A biomedical telemetry transmitter according to claim 25 wherein the biomedical sensors are connected to the patient at predetermined positions on the body of the patient and wherein said telemetry transmitter includes a visual display means coupled to said ascertaining means for providing a visual indication of the position of a disconnected biomedical sensor on the body of the patient.

27. A biomedical telemetry transmitter according to claim 23 wherein said input circuit comprises:

a conductor having a terminal to which one of the biomedical sensors can be coupled;

a differential amplifier, said differential amplifier having one input connected to said conductor, said differential amplifier providing an output signal;

means providing a reference signal to another input of said differential amplifier;

a current source connected to said conductor intermediate said terminal and said one input of said amplifier, the loss of the connection of the one of the biomedical sensors to the patient causing said current source to generate a voltage at said one input; and

means for measuring the change in the output of said differential amplifier responsive to the generation of the voltage at said one input for determining the loss of the sensor-patient connection and for providing an indication of same to said control means.

28. A biomedical telemetry transmitter according to claim 27 wherein said input circuit determines the impedance of a connection of the one of the biomedical sensors to the body of the patient, said input circuit further comprising means for altering the current produced by said current source, and wherein said measuring means is further defined as measuring the change in the output of said differential amplifier responsive to the alteration of the current from said current source for determining the impedance of the sensor-patient connection.

29. A biomedical telemetry transmitter according to claim 28 wherein said signal from the one of the biomedical sensors is subject to variation as a result of the physiological functioning of the patient, wherein said current altering means is further defined as means for periodically altering the current;

wherein said measuring means is further defined as means for repetitiously measuring the output of said differential amplifier; and

wherein said measuring means includes means for averaging repetitious measurements for lessening the effect of said variation in the determination of the sensor connection impedance.

30. A biomedical telemetry transmitter according to claim 28 wherein the biomedical sensors comprise electrocardiographic electrodes and wherein said input circuit is further defined as including means for determining the impedance of the connection of one of the electrocardiographic electrodes to the body of a patient.

31. A biomedical telemetry transmitter according to claim 27 wherein said input circuit has a second conductor having a second terminal to which a second sensor of said plurality of sensors can be coupled, said second conductor being connected to said another input of said differential amplifier for supplying the analog input signal of said second sensor to said another input of said differential amplifier, said input circuit further including means connected to said second conductor for causing said signal in said second conductor to form said reference signal to said another input of the differential amplifier.

32. A biomedical telemetry transmitter according to claim 31 wherein said input circuit is further defined as detecting the loss of connection of the second sensor from the body of the patient, and wherein said input circuit further comprises:

a second amplifier having a pair of inputs, said second conductor being connected to a third conductor for supplying the signal from said second sensor to one input of said second amplifier;

a reference source connected to the other input of said second amplifier;

a second current source connected to said second conductor intermediate said second terminal and the connection of said third conductor to said second conductor;

means for generating a voltage at said one input of said first amplifier upon the loss of the second sensor-patient connection; and

wherein said measuring means is further defined as measuring the change in the output of said differential amplifier responsive to the generation of the voltage at said one input for determining the loss of said second sensor-patient connection.

33. A biomedical telemetry transmitter according to claim 32 wherein said input circuit is further defined as determining the impedance of the connection of the first and second sensors to the body of the patient, wherein said input circuit includes means for intermittently altering the current produced by said first current source or said second current source in a manner such that intervals exist when the current of one source is altered but the current of the other source is not altered, and wherein said measuring means is further defined as measuring the change in the outputs of said first differential amplifier and said second differential amplifier responsive to the alteration of the current from said first and second current sources for determining the impedance of the first sensor-patient connection and the second sensor-patient connection.

34. A biomedical telemetry transmitter according to claim 25 wherein the biomedical sensors comprise electrocardiographic electrodes and wherein said input circuit is further defined as including means for determining the loss of the connection of one of the electrocardiographic electrodes to the body of the patient.

35. A biomedical telemetry transmitter according to claim 1 wherein said analog/digital converter comprises an eight channel, 20-bit analog/digital converter sampling the analog input signals at a frequency of 10 KHz and providing a digital output having a frequency of 500 Hz.

36. A biomedical telemetry transmitter according to claim 1 wherein the plurality of biomedical data signals comprise EKG data signals containing pacemaker spikes, wherein said analog/digital converter includes means for sampling the biomedical data-signals at sampling intervals, wherein said analog/digital converter has a slew rate detector detecting change in the data signals between two successive signal samples, and wherein said slew rate detector detects said pacemaker spike signals from the data signal change in successive samples and provides a signal in accordance therewith to said control means.

37. A biomedical telemetry transmitter according to claim 1 wherein said control means is further defined as including means for providing a digital modulating signal having a data rate up to 40 Kilobits/second.

38. A biomedical telemetry transmitter according to claim 37 wherein said rf signal generating means is further defined as rf signal generating means having a 100 KHz bandwidth.

39. A biomedical telemetry transmitter according to claim 1 wherein the biomedical data signals are further defined as eight EKG signals, wherein said analog/digital converter is further defined as an analog/digital converter having a 500 Hz sampling rate, and wherein said control means is further defined as including means for providing a digital modulating signal having a 40 Kilobits/second data rate.

40. A biomedical telemetry transmitter according to claim 1 wherein the telemetry transmitter is further defined as a telemetry transmitter for transmitting a plurality of EKG data signals.

41. A biomedical telemetry transmitter according to claim 1 wherein said control means includes a microprocessor coupled to said input circuit and to said rf signal generating means.

42. A biomedical telemetry transmitter according to claim 1 wherein said rf signal generating means includes a phase locked loop coupled to said control means for generating the rf carrier signal.

43. A biomedical telemetry transmitter according to claim 1 wherein said transmitter has a transmitting antenna coupled to said rf signal generating means, wherein said rf signal generating means reduces frequency alteration of the rf carrier signal resulting from changes in antenna loading reflected to the rf signal generating means while maintaining the quality of the data modulation of the rf carrier signal, and wherein said rf carrier signal generating means includes an oscillator providing an rf carrier signal to the antenna, said oscillator being incorporated in a control loop having a frequency bandwidth within which said control loop acts to establish and maintain the frequency of the rf carrier signal, said oscillator receiving the digital modulating signal having a frequency characteristic extending over a range of frequencies, said rf signal generating means further including means for establishing the bandwidth of said control loop to a width such that the control loop can maintain the frequency of the rf carrier signal when the rf signal generating means is subjected to changes in reflected antenna loading, said bandwidth of said control loop, so established, overlapping a low frequency portion of the frequency range of the digital modulating signal;

and

preemphasis circuit means for increasing the magnitude of said low frequency portion of the digital modulating signal to maintain the modulation of the rf carrier signal.

44. A biomedical telemetry transmitter according to claim 43 wherein said preemphasis circuit means is further defined as means for providing an adjustable amount of magnitude increase to said low frequency portion of the digital modulating signal.

45. A biomedical telemetry transmitter according to claim 44 wherein said preemphasis circuit means includes an adjustable resistor for adjusting the amount of magnitude increase, wherein said oscillator exhibits a sensitivity between input signal magnitude and output frequency, and wherein said adjustable resistor is coupled to the input of said oscillator means for compensating said oscillator means for variations in sensitivity.

46. A biomedical telemetry transmitter according to claim 1 wherein the plurality of biomedical data signals originate at biomedical sensors comprising electrodes applied to the torso of a patient, and wherein said telemetry transmitter includes a display means for providing a display indicating the electrical condition of the electrodes, each of said electrodes having an identification and being applied at predetermined locations on the torso of the patient, the electrical condition of said electrodes being determined by said input circuit, said display means comprising:

means presenting a surface on which visibly discernible patterns may be formed;

means coupled to said surface means and operable to form a visibly discernible outline of a human torso in said surface;

means coupled to said surface means and operable to provide an indication, in said surface, of the location and identification of the electrodes on the torso outline representing the corresponding electrode identification and locations on the torso of the patient; and

means coupled to said input circuit and to said indication means for operating said indication providing means to indicate the location and identification of an electrode having an electrical condition determined to be faulty by said input circuit.