Electroporation and iontophoresis catheter with porous balloon
First Claim
1. An electroporation apparatus for introducing molecules into cells at a selected location within a cavity in the body of a patient, comprising:
- an elongated catheter having a proximal end and a distal end and a guide wire extending from said proximal end to said distal end;
an inflatable balloon carried by said distal end, said balloon having an inner inflatable bladder and an outer perforated bladder defining a chamber therebetween;
means defining a first electrode on an outer surface of the inflatable portion of said outer perforated bladder;
means associated with said distal end defining a second electrode spaced from said first electrode;
means for delivering a predetermined quantity of a fluid medium carrying preselected molecules into said chamber to be infused into said body cavity at the predetermined location; and
means for applying a voltage pulse between said first electrode and said second electrode for repeatedly generating electric fields of a predetermined amplitude and duration inducing the walls of a plurality of cells at the predetermined location to be transiently permeable to enable the molecules to enter said cells.
1 Assignment
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Accused Products
Abstract
An electroporation apparatus for introducing molecules into cells at a selected location within a cavity in the body of a patient includes an elongated catheter having a proximal end and a distal end and a guide wire extending from the proximal end to the distal end, an inflatable balloon carried by the distal end, the balloon having an inner inflatable bladder and an outer perforated bladder defining a chamber between the two bladders, a first electrode on an outer surface of the outer perforated bladder, a second electrode spaced from the first electrode, a remote electrode, a lumen for delivering a predetermined quantity of a fluid medium carrying preselected molecules into the chamber to be infused into the body cavity at the predetermined location; and a source of power for applying a voltage pulse between selected pairs of the electrodes for transport of the molecules by iontophoresis and/or repeatedly generating electric fields of a predetermined amplitude and duration inducing the walls of a plurality of cells at the predetermined location to be transiently permeable to enable the molecules to enter the cells.
313 Citations
25 Claims
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1. An electroporation apparatus for introducing molecules into cells at a selected location within a cavity in the body of a patient, comprising:
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an elongated catheter having a proximal end and a distal end and a guide wire extending from said proximal end to said distal end; an inflatable balloon carried by said distal end, said balloon having an inner inflatable bladder and an outer perforated bladder defining a chamber therebetween; means defining a first electrode on an outer surface of the inflatable portion of said outer perforated bladder; means associated with said distal end defining a second electrode spaced from said first electrode; means for delivering a predetermined quantity of a fluid medium carrying preselected molecules into said chamber to be infused into said body cavity at the predetermined location; and means for applying a voltage pulse between said first electrode and said second electrode for repeatedly generating electric fields of a predetermined amplitude and duration inducing the walls of a plurality of cells at the predetermined location to be transiently permeable to enable the molecules to enter said cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. An electroporation catheter for introducing molecules into cells at a selected location within a cavity in the body of a patient, comprising:
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an elongated catheter having a proximal end and a distal end and a guide wire extending from said proximal end to said distal end; an inflatable balloon carried by said distal end, said balloon having an inner inflatable bladder and an outer perforated bladder having perforations defining a chamber therebetween; said outer perforated bladder having a conductive outer surface defining a first electrode on the inflatable portion of said perforated bladder for engagement with walls of said cavity; a second electrode spaced from said first electrode carried by Said distal end of said catheter; means for delivering a predetermined quantity of a fluid medium carrying preselected molecules into said chamber for infusing via said perforations into said cavity at the predetermined location; and conductor means at said proximal end of said catheter for connecting to a power source for applying a voltage pulse between said first electrode and said second electrode for repeatedly generating electric fields of a predetermined amplitude and duration inducing the walls of a plurality of cells at the predetermined location to be transiently permeable to enable the molecules to enter said cells. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25)
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Specification