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Target-specific, cytotoxic, recombinant pseudomonas exotoxin

  • US 5,705,163 A
  • Filed: 06/05/1995
  • Issued: 01/06/1998
  • Est. Priority Date: 01/02/1990
  • Status: Expired due to Fees
First Claim
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1. A method for killing a target cell, said method comprising contacting said target cell with a cytotoxic amount of a composition comprising a recombinant Pseudomonas exotoxin (PE) having a first recognition molecule for binding said target cell and a carboxyl terminal sequence of 4 to 16 amino acids which permits translocation of the PE molecule into a cytosol of said target cell, the first recognition molecule being inserted in domain III after and no acid 600 and before amino acid 613 of the PE.

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