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Microcapsules prepared from crosslinkable polysaccharides, polycations and/or lipids and use therefor

  • US 5,705,270 A
  • Filed: 06/07/1995
  • Issued: 01/06/1998
  • Est. Priority Date: 10/29/1991
  • Status: Expired due to Term
First Claim
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1. Microcapsules comprising biologically active material encapsulated in a modified biocompatible material which has been subjected to free radical polymerization under biocompatible conditions in an aqueous media that is free of organic solvents, wherein said material has the formula:

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    space="preserve" listing-type="equation">A--Xwherein;

    A is selected from the group consisting of polysaccharides, polycations and lipids,X is a moiety containing a carbon-carbon double bond or triple bond capable of free radical polymerization; and

    A and X are linked covalently through linkages selected from the group consisting of ester, ether, thioether, disulfide, amide, secondary amines, tertiary amines, direct C--C linkages, sulfate esters, sulfonate esters, phosphate esters, urethanes, and carbonates; and

    wherein the largest physical dimension of said microcapsule, including the encapsulated material, does not exceed 1 mm.

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