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Analytical devices and methods of use

  • US 5,705,397 A
  • Filed: 08/25/1995
  • Issued: 01/06/1998
  • Est. Priority Date: 03/04/1993
  • Status: Expired due to Fees
First Claim
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1. An analytical device for use in assay procedures, comprising at least one liquid flow channel of porous material for capillary liquid flow therealong, the channel having:

  • a channel end for liquid application thereto,an analytical site, said channel defining a liquid flow path leading in a downstream direction from said channel end to said analytical site,a localized reagent site said channel end and said analytical site, anda permanent liquid impermeable barrier in said channel between said channel end and said analytical site, said barrier being constructed and adapted to create a substantially stagnant zone by intercepting said liquid flow path and extending partially across the channel width, sufficiently close to said localized reagent site that, on application of a reagent to said localized reagent site and application of liquid to said channel end, said substantially stagnant zone is created whereby the distribution of said reagent is elongated as it is delivered from said reagent site to said analytical site by entrainment in said capillary flow.

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