Linear microdialysis probe with support fiber
First Claim
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1. An improved linear microdialysis probe assembly, adapted for sampling the interstitial fluid of a variety of soft tissues in living animals, comprising:
- a length of plastic tubing having a tubular semipermeable membrane window intermediate its ends, and a length of flexible support fiber positioned within and attached to the tubing and extending at least through the tubular membrane window.
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Abstract
An improved linear microdialysis probe assembly has a short semipermeable membrane portion containing a flexible, internal support or reinforcement fiber bonded to long lengths of inlet and outlet robing. Also disclosed is a method of using it to sample the interstitial fluid of a variety of soft tissues in a living animal including dermis, muscle, adipose and subcutaneous tissue, liver and tumors by pulling the fiber, and attached probe, through the tissue of interest with a needle until the membrane is positioned where desired.
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Citations
9 Claims
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1. An improved linear microdialysis probe assembly, adapted for sampling the interstitial fluid of a variety of soft tissues in living animals, comprising:
- a length of plastic tubing having a tubular semipermeable membrane window intermediate its ends, and a length of flexible support fiber positioned within and attached to the tubing and extending at least through the tubular membrane window.
- View Dependent Claims (2, 3, 4)
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5. A method of inserting a microdialysis probe, of the type having a length of plastic tubing having a tubular semipermeable membrane window intermediate its ends and a length of flexible support fiber positioned within and attached to the tubing and extending at least through the tubular membrane window, into a live animal to sample the interstitial fluid of soft tissues therein, the method comprising the step of:
- pulling one end of the fiber, and thus the attached probe, through the tissue with a needle until the membrane window is positioned where desired.
- View Dependent Claims (6)
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7. A microdialysis probe assembly, comprising:
- a semipermeable hollow membrane, hollow tubing connected to the membrane, and a support fiber removably attached to the tubing and positioned within the tubing and the membrane when attached to the tubing.
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8. A method of controlling the percent relative recovery of a microdialysis probe comprising a hollow membrane, hollow tubing connected to the membrane, and a support fiber removably attached to the tubing and positioned within the tubing and membrane when attached to the tubing, the method comprising the steps of:
- implanting the probe having the support fiber attached to the tubing, detaching the fiber from the tubing, and removing the fiber from the probe so that it no longer resides within the membrane, to thereby increase the percent relative recovery of the probe in the presence of a constant flow rate of a perfusion promp connected to the tubing.
- View Dependent Claims (9)
Specification