Magnetic resonance imaging assisted cryosurgery

• US 5,706,810 A
• Filed: 06/02/1995
• Issued: 01/13/1998
• Est. Priority Date: 03/23/1993
• Status: Expired due to Fees

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Wong, San, Gilbert, John, Pease, Grant, Roos, Mark, Rubinsky, Boris
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/461,253
• Time in Patent Office: 956 Days
• Field of Search: 128/736, 128/653.1, 324/315, 606/20, 606/21
• US Class Current: 600/412
• CPC Class Codes: A61B 18/02 by cooling, e.g. cryogenic techniques devices for cooling specific reflex points of the body within cell-life limits A61H39/06
• CPC Class Codes: A61B 2018/0262 using a circulating cryogenic fluid
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 90/10 for stereotaxic surgery, e.g. frame-based stereotaxis
• CPC Class Codes: G01R 33/28 Details of apparatus provided for in groups G01R33/44 - G01R33/64
• CPC Class Codes: G01R 33/56308 Characterization of motion or flow; Dynamic imaging

Abstract

Methods and apparatus for magnetic resonance imaging (MRI) assisted cryosurgery. Optimal probe placements and cooling parameters are calculated prior to cryosurgery using MRI data. A MRI compatible cryoprobe and a stereotactic probe positioning device are provided. The resolution of MR images is enhanced by mounting a radio frequency MR coil on the intracorporeal end of a cryoprobe. During cryosurgery the temperature distribution in the frozen region is solved by determining the boundary of the frozen region and solving the heat equation for the known boundary conditions. During cryosurgery the temperature distribution in the unfrozen region is determined by T1 measurements. The process of freezing is controlled using information from the solution of the energy equation in the frozen region and temperature measurements in the unfrozen region. After cryosurgery the extent of the tissue damage may be ascertained using phosphorus-31 and/or sodium-23 spectroscopy with a special coil set on the cryosurgical probe.

Claims

1. A method for monitoring temperatures of a target region in a biological tissue with a magnetic resonance imaging technique and a cryoprobe, said target region including a frozen region having a first temperature distribution, an unfrozen region having a second temperature distribution, and an interfacial surface bounding said frozen region, comprising the steps of:

generating an image of said target region with said magnetic resonance imaging technique;

determining the location of said frozen region using the image so generated;

determining a temperature at said interfacial surface;

solving a heat equation for the interior of said frozen region utilizing the temperature at said interfacial surface to determine said first temperature distribution in said frozen region;

determining said second temperature distribution in said unfrozen region, and

using said first and second temperature distributions determined to monitor the temperature of said target region.

2. The method of claim 1 further comprising accomplishing the step of determining the location of said frozen region by correlating a region that generates a low magnetic resonance signal with said frozen region.

3. The method of claim 2 further comprising the step of displaying said magnetic resonance image and said first temperature distribution.

4. The method of claim 2 further comprising the step of displaying said magnetic resonance image and said second temperature distribution.

5. The method of claim 2 wherein said interfacial surface includes the surface of said cryoprobe.

6. A method for utilizing information obtained from magnetic resonance imaging of a target region to control real-time cryosurgical parameters, said target region including a frozen region having a first temperature distribution, an unfrozen region having a second temperature distribution, and an interfacial surface bounding said frozen region, comprising the steps of:

generating an image of said target region with a magnetic resonance imaging technique;

identifying said frozen region as a section of the image so generated having no magnetic resonance signal;

determining a temperature at said interfacial surface;

solving the heat equation for the interior of said frozen region utilizing a temperature at said interfacial surface to determine said first temperature distribution in said frozen region;

measuring nuclear relaxation times in said unfrozen region by a magnetic resonance technique;

determining said second temperature distribution in said unfrozen region by calculations based on said nuclear relaxation times as measured by said magnetic resonance technique; and

affecting said cryosurgical parameters according to said first and second temperature distributions to achieve a desired result.

7. The method of claim 6 wherein said cryosurgical parameters include a flow of cryogen to a cryoprobe.

8. The method of claim 6 further comprising the step of displaying said magnetic resonance image and said first temperature distribution.

9. The method of claim 6 further comprising the step of displaying said magnetic resonance image and said second temperature distribution.

10. A method for monitoring temperatures of a target region in a biological tissue with a magnetic resonance imaging technique and a cryoprobe, said target region including a frozen region having a first temperature distribution, an unfrozen region having a second temperature distribution, and an interfacial surface bounding said frozen region, comprising the steps of:

generating an image of said target region with said magnetic resonance imaging technique;

identifying said frozen region as corresponding to a section of the image so generated having a low magnetic resonance signal;

determining a temperature at said interfacial surface;

solving a heat equation for the interior of said frozen region utilizing the temperature at said interfacial surface to determine said first temperature distribution in said frozen region;

measuring nuclear relaxation times in said unfrozen region by a magnetic resonance technique;

determining said second temperature distribution using calculations based on said nuclear relaxation times measured in said unfrozen region; and

using said first and second temperature distributions determined to monitor the temperature of said target region.

11. The method of claim 10 wherein said magnetic resonance technique is a spoiled radio frequency technique.

12. The method of claim 10 wherein said magnetic resonance technique is a spin-echo technique.

14. The method of claim 10, wherein said temperature at said interfacial surface is determined by the composition of said biological tissue and thermodynamic phase equilibrium at the interface.

13. A method for monitoring temperatures of a target region in a biological tissue with a magnetic resonance imaging technique and a cryoprobe, said target region including a frozen region having a first temperature distribution, an unfrozen region having a second temperature distribution, and an interfacial surface bounding said frozen region, comprising the steps of:

generating an image of said target region with said magnetic resonance imaging technique;

determining the location of said frozen region using the image so generated;

solving a heat equation for the interior of said frozen region using a temperature of approximately -0.56 degrees Celsius as the temperature at said interfacial surface to determine said first temperature distribution in said frozen region;

determining said second temperature distribution for said unfrozen region; and

using said first and second temperature distributions determined to monitor the temperature of said target region.