Pulmonary delivery of therapeutic agent

• US 5,707,352 A
• Filed: 06/07/1995
• Issued: 01/13/1998
• Est. Priority Date: 08/28/1989
• Status: Expired due to Term

• Current Assignee: Temple University of The Commonwealth System of Higher Education
• Original Assignee: Alliance Pharmaceutical Corporation
• Inventors: Wolfson, Marla R., Shaffer, Thomas H., Sekins, K. Michael
• Primary Examiner(s): Buiz, Michael Powell
• Assistant Examiner(s): SMITH, CHALIN A
• Application Number:
  US08/480,455
• Time in Patent Office: 951 Days
• Field of Search: 128/207.14, 128/898, 128/200.23, 128/200.24, 128/913, 604/20, 604/22, 604/23, 604/49, 604/56, 604/57, 604/26-28
• US Class Current: 604/509
• CPC Class Codes: A61B 2017/22054 with two balloons
• CPC Class Codes: A61B 2018/00011 with fluids
• CPC Class Codes: A61F 2007/0054 with a closed fluid circuit, e.g. hot water
• CPC Class Codes: A61F 7/123 using a flexible balloon containing the thermal element
• CPC Class Codes: A61K 9/0026 Blood substitute; Oxygen transporting formulations; Plasma extender
• CPC Class Codes: A61M 16/0404 with means for selective or partial lung respiration
• CPC Class Codes: A61M 16/0454 Redundant cuffs
• CPC Class Codes: A61M 16/0459 one cuff behind another
• CPC Class Codes: A61M 16/0463 combined with suction tubes, catheters or the like; Outside connections
• CPC Class Codes: A61M 16/0479 above the cuff, e.g. giving access to the upper trachea
• CPC Class Codes: A61M 16/0486 Multi-lumen tracheal tubes
• CPC Class Codes: A61M 2202/0468 non-physiological
• CPC Class Codes: A61M 2202/0476 Oxygenated solutions
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61N 7/022 intracavitary
• CPC Class Codes: B06B 1/0633 Cylindrical array
• CPC Class Codes: Y10S 128/913 Breathable liquids
• CPC Class Codes: Y10T 137/87652 With means to promote mixing or combining of plural fluids

Abstract

An apparatus for producing a uniformly dispersed drug-containing phase within a continuous liquid delivery phase.

Claims

1. A process for controlling, diagnosing or treating physiological conditions, diseases or abnormalities of a patient, said process comprising:

providing a liquid medium comprising at least one solid or liquid therapeutic or diagnostic agent distributed in a breathable liquid carrier; and

passing said liquid medium through at least a portion of said patient'"'"'s pulmonary air passages.

2. A process according to claim 1 further comprising the step of selecting a patient suffering from respiratory distress syndrome.

3. A process according to claim 1 further comprising selecting said therapeutic or diagnostic agent from the group consisting of, antibody-linked radionuclides, vasoconstrictors, vasodilators, bronchoconstrictors, bronchodilators, anti-cancer agents, surfactants, steroids, antibiotic agents, chemotactic agents, chemotherapeutic agents, contrast agents and combinations thereof.

4. A process according to claim 1 further comprising distributing said therapeutic or diagnostic agent in a form selected from the group consisting of a suspension, a dispersion, an encapsulation, an emulsion and combinations thereof.

5. A process according to claim 1 further comprising the step of removing said liquid medium from said pulmonary passages.

6. A process according to claim 1 further comprising selecting a powdered therapeutic or diagnostic agent.

7. A process according to claim 1 further comprising the step of heating said liquid medium above the body temperature of the patient.

8. A process according to claim 1 further comprising selecting said breathable liquid carrier from the group consisting of fluorocarbon liquids, saline, silicone liquids, vegetable oils and combinations thereof.

9. A process according to claim 8 further comprising selecting a breathable liquid carrier comprising a perfluorocarbon characterized by an average molecular weight in the range of from about 350 to about 560.

10. A process according to claim 8 further comprising the step of selecting a breathable liquid carrier comprising a fluorocarbon.

11. A method for performing liquid lavage to control, diagnose or treat physiological conditions, diseases or abnormalities of a patient, said method comprising the steps of:

providing a liquid medium comprising at least one solid or liquid therapeutic or diagnostic agent distributed in a breathable liquid carrier;

delivering said liquid medium into at least a portion of the patient'"'"'s pulmonary air passages; and

removing the liquid medium from said at least a portion of the patient'"'"'s pulmonary air passages.

12. A method according to claim 11 further comprising selecting said therapeutic or diagnostic agent from the group consisting of toxins, antibody-linked radionuclides, vasoconstrictors, vasodilators, bronchoconstrictors, bronchodilators, anti-cancer agents, surfactants, steroids, antibiotic agents, chemotactic agents, chemotherapeutic agents, contrast agents and combinations thereof.

13. A method according to claim 11 further comprising distributing said therapeutic or diagnostic agent in a form selected from the group consisting of a suspension, a dispersion, an encapsulation, an emulsion and combinations thereof.

14. A method according to claim 11 further comprising selecting said breathable liquid carrier from the group consisting of fluorocarbon liquids, saline, silicone liquids, vegetable oils and combinations thereof.

15. A method for performing liquid ventilation to control, diagnose or treat physiological conditions, diseases or abnormalities of a patient, said method comprising the steps of:

dispersing a solid or liquid therapeutic or diagnostic agent in a fluorocarbon liquid to provide a bioactive liquid medium;

administering said bioactive liquid medium into at least a portion of the patient'"'"'s pulmonary air passages; and

introducing a breathing gas into said at least a portion of the patient'"'"'s pulmonary air passages whereby pulmonary gas exchange is maintained.

16. A method according to claim 15 further comprising selecting said therapeutic or diagnostic agent from the group consisting of toxins, antibody-linked radionuclides, vasoconstrictors, vasodilators, bronchoconstrictors, bronchodilators, anti-cancer agents, surfactants, steroids, antibiotic agents, chemotactic agents, chemotherapeutic agents, contrast agents and combinations thereof.

17. A method according to claim 15 further comprising dispersing said therapeutic or diagnostic agent in a form selected from the group consisting of a suspension, an encapsulation, an emulsion and combinations thereof.

18. A method according to claim 15 further comprising selecting a powdered therapeutic or diagnostic agent.

19. A method according to claim 15 further comprising selecting a fluorocarbon characterized by an average molecular weight in the range of from about 350 to about 560.