Method of arresting degeneration of the substantia nigra by high frequency stimulation of subthalamic nucleus

• US 5,707,396 A
• Filed: 04/25/1996
• Issued: 01/13/1998
• Est. Priority Date: 04/25/1996
• Status: Expired due to Term

• Current Assignee: Institut National De La Sante Et De La Recherche Medicale (Inserm) (Allianz Global Investors GmbH)
• Original Assignee: Institut National De La Sante Et De La Recherche Medicale (Inserm) (Allianz Global Investors GmbH)
• Inventors: Benabid, Alim
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/637,438
• Time in Patent Office: 628 Days
• Field of Search: 607/72, 607/45, 607/117, 607/118, 607/2, 128/642, 128/898, 128/899
• US Class Current: 607/2
• CPC Class Codes: A61N 1/326 for promoting growth of cells, e.g. bone cells

Abstract

A method of preventing further degeneration of the substantia nigra observed in patients with Parkinson'"'"'s disease. High frequency electrical pulses are supplied to the subthalamic nucleus thereby blocking stimulation of the subthalamic nucleus

Claims

1. A method of preventing further degeneration of a substantia nigra of a brain of a patient with Parkinson'"'"'s disease by means of a signal generator and an implantable electrode having a proximal end and a stimulation portion utilized in conjunction with a subthalmic nucleus of said brain, said method comprising the steps of:

surgically implanting said electrode in the brain so that the stimulation portion lies in the subthalmic nucleus of the brain;

coupling said proximal end of said electrode to said signal generator; and

operating said signal generator at a predetermined repetition rate high enough to block activity of the subthalmic nucleus to inhibit excessive release of glutamate at the terminal ends of the axons projecting from the subthalamic nucleus to the substantia nigra.

2. A method, as claimed in claim 1, wherein said repetition rate is about 10-2500 Hz.