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Biodegradable gelatin-aminodextran particle coatings of and processes for making same

  • US 5,707,877 A
  • Filed: 06/23/1995
  • Issued: 01/13/1998
  • Est. Priority Date: 10/31/1990
  • Status: Expired due to Fees
First Claim
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1. A method of preparing aminodextran compounds in aqueous solution comprising:

  • (a) partially oxidizing a dextran compound to dextran aldehyde using a chemical oxidizing agent such as sodium periodate at ambient room temperature;

    (b) desalting the dextran-aldehyde solution of step (a);

    (c) reacting the dextran-aldehyde of step (b) with a diamine at a temperature of about 5-10°

    C. to form a plurality of Schiff'"'"'s base linkages between the dextran-aldehyde and amino groups of the diamine; and

    (d) reducing the Schiff'"'"'s base linkages of step (c) to obtain an amino-dextran through the use of a chemical reducing agent.

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