Zinc gluconate gel compositions

• US 5,708,023 A
• Filed: 06/28/1995
• Issued: 01/13/1998
• Est. Priority Date: 03/28/1994
• Status: Expired due to Term

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Modak, Shanta M., Sampath, Lester A., Advani, Balram H.
• Primary Examiner(s): Jarvis, William R. A.
• Application Number:
  US08/492,080
• Time in Patent Office: 930 Days
• Field of Search: 424/642, 514/494, 514/635
• US Class Current: 514/494
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 25/32 Ingredients for reducing the noxious effect of the active substances to organisms other than pests, e.g. toxicity reducing compositions, self-destructing compositions
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 37/40 having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
• CPC Class Codes: A01N 39/00 Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or , e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/03 aromatic
• CPC Class Codes: A61K 31/055 the aromatic ring being substituted by halogen
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/191 having two or more hydroxy groups, e.g. gluconic acid
• CPC Class Codes: A61K 31/765 Polymers containing oxygen
• CPC Class Codes: A61K 33/18 Iodine; Compounds thereof
• CPC Class Codes: A61K 33/30 Zinc; Compounds thereof
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 13/02 : of urine or of the urinary tract, e.g. urine acidifiers
• CPC Class Codes: A61P 15/00 : Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 31/02 : Local antiseptics
• CPC Class Codes: A61P 31/04 : Antibacterial agents
• CPC Class Codes: A61P 37/08 : Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14

Abstract

A composition of matter containing zinc gluconate gel as an irritant-inactivating agent, and a substance which substantially prevents the irritant-inactivating agent from binding to the surface, wherein the irritant-inactivating agent in the composition is present in an amount effective to inactivate irritants in fluids which contact the composition, is described. Surgical instruments and physical barriers with the aforementioned composition applied thereto are also described. A method of inactivating irritants in a fluid contacting skin comprising applying the aforementioned composition to the skin is also disclosed. A method of inactivating irritants in a fluid contacting skin covered with a physical barrier comprising applying the aforementioned composition to the skin is also disclosed.

Claims

1. A composition comprising a gel matrix formed from zinc gluconate and a solvent selected from the group consisting of water, alcohol, and combinations thereof, wherein the zinc gluconate acts as the sole gelling agent.

2. The composition of claim 1, wherein the gel matrix comprises 50% zinc gluconate.

3. The composition of claim 1 which comprises at least 10% zinc gluconate.

4. The composition of claim 2 which comprises at least 10% zinc gluconate.

5. The composition of claim 1 wherein the gel matrix comprises a therapeutically effective amount of chlorhexidine or a pharmaceutically acceptable chlorhexidine salt.

6. The composition of claim 1 wherein the gel matrix comprises a therapeutically effective amount of an antimicrobial agent selected from the group consisting of parachlorometaxylenol, triclosan, povidone iodine, benzalkonium chloride, a silver salt, and a polyoxyethylene alkylphenol compound.

7. The composition of claim 1 wherein the gel matrix comprises a therapeutically effective amount of an anti-allergen.

8. The composition of claim 3 wherein the gel matrix comprises a therapeutically effective amount of chlorhexidine or a pharmaceutically acceptable chlorhexidine salt.

9. The composition of claim 3 wherein the gel matrix comprises a therapeutically effective amount of an antimicrobial agent selected from the group consisting of parachlorometaxylenol, triclosan, povidone iodine, benzalkonium chloride, a silver salt, and a polyoxyethylene alklylphenol compound.

10. The composition of claim 3 wherein the gel matrix comprises a therapeutically effective amount of an anti-allergen.

11. The composition of claim 4 wherein the gel matrix comprises a therapeutically effective amount of chlorhexidine or a pharmaceutically acceptable chlorhexidine salt.

12. The composition of claim 4 wherein the gel matrix comprises a therapeutically effective amount of an antimicrobial agent selected from the group consisting of parachlorometaxylenol, triclosan, povidone iodine, benzalkonium chloride, a silver salt, and a polyoxyethylene alkylphenol compound.

13. The composition of claim 4 wherein the gel matrix comprises a therapeutically effective amount of anti-allergen.

14. The composition of claim 5 which comprises between about 0.5% to 10% chlorhexidine or a pharmaceutically acceptable chlorhexidine salt.

15. The composition of claim 14 which comprises between about 0.5% to 5% chlorhexidine or a pharmaceutically acceptable chlorhexidine salt.

16. The composition of claim 8 which comprises between about 0.5% to 10% chlorhexidine or a pharmaceutically acceptable chlorhexidine salt.

17. The composition of claim 16 which comprises between about 0.5% to 5% chlorhexidine or a pharmaceutically acceptable chlorhexidine salt.

18. The composition of claim 11 which comprises between about 0.5% to 10% chlorhexidine or a pharmaceutically acceptable chlorhexidine salt.

19. The composition of claim 18 which comprises between about 0.5% to 5% chlorhexidine or a pharmaceutically acceptable chlorhexidine salt.

20. The composition of claim 1 which is a topical antimicrobial cream.

21. The composition of claim 5 which is a topical antimicrobial cream.

22. The composition of claim 6 which is a topical antimicrobial cream.

23. The composition of claim 7 which is a topical antimicrobial cream.

24. The composition of claim 1 which is a vaginal cream.

25. The composition of claim 5 which is a vaginal cream.

26. The composition of claim 6 which is a vaginal cream.

27. The composition of claim 7 which is a vaginal cream.

28. The composition of claim 1 which is applicable to a wound dressing.

29. The composition of claim 5 which is applicable to a wound dressing.

30. The composition of claim 6 which is applicable to a wound dressing.

31. The composition of claim 7 which is applicable to a wound dressing.

32. The composition of claim 1 which is applicable to a surgical instrument.

33. The composition of claim 5 which is applicable to a surgical instrument.

34. The composition of claim 6 which is applicable to a surgical instrument.

35. The composition of claim 7 which is applicable to a surgical instrument.

36. The composition of claim 1 which is applicable to a glove.

37. The composition of claim 5 which is applicable to a glove.

38. The composition of claim 6 which is applicable to a glove.

39. The composition of claim 7 which is applicable to a glove.

40. The composition of claim 1 which is applicable to a condom.

41. The composition of claim 5 which is applicable to a condom.

42. The composition of claim 6 which is applicable to a condom.

43. The composition of claim 7 which is applicable to a condom.

44. A method of preventing skin irritation comprising applying, to the skin, a composition comprising a gel matrix formed from zinc gluconate and a solvent selected from the group consisting of water, alcohol, and combinations thereof, wherein the zinc gluconate acts as the sole gelling agent.